Results 51 to 60 of about 794,201 (275)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Zero-shot visual reasoning through probabilistic analogical mapping

Nature Communications, 2023
Human reasoning is grounded in an ability to identify highly abstract commonalities governing superficially dissimilar visual inputs. Recent efforts to develop algorithms with this capacity have largely focused on approaches that require extensive direct
Taylor Webb, Shuhao Fu, Trevor Bihl, Keith J. Holyoak, Hongjing Lu   +4 more
doaj   +1 more source

Combinatorial and Proportional Task: Looking for Intuitive Strategies in Primary Education

Mathematics, 2022
The development of probabilistic thinking at school requires enhancing combinatorial and proportional reasoning. For this reason, 190 sixth-grade elementary school students (11–12-year-old), without previous instruction in the topic, solve a task ...
Maria Ricart, Assumpta Estrada
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A Model of Scientific Data Reasoning

Education Sciences, 2022
Data reasoning is an essential component of scientific reasoning, as a component of evidence evaluation. In this paper, we outline a model of scientific data reasoning that describes how data sensemaking underlies data reasoning.
Amy M. Masnick, Bradley J. Morris
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Combatting bayesian criticism: a bayesian-inspired critical checklist for judicial reasoning

Quaestio Facti
This paper develops a Bayesian-inspired checklist of critical questions designed to support probabilistic reasoning in legal contexts. Building on Mackor’s (2026) proposal, rather than requiring formal Bayesian models or numerical probabilities, the ...
Leya Lisa Hampson
doaj   +1 more source

The probabilistic approach to human reasoning [PDF]

Trends in Cognitive Sciences, 2001
A recent development in the cognitive science of reasoning has been the emergence of a probabilistic approach to the behaviour observed on ostensibly logical tasks. According to this approach the errors and biases documented on these tasks occur because people import their everyday uncertain reasoning strategies into the laboratory.
M, Oaksford, N, Chater
openaire   +2 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source