Results 61 to 70 of about 1,830,065 (298)

Estimation of Threshold Effect of Kenyan Shilling Exchange Rate on Rwandan Economy: A Semiparametric Model Approach

open access: yesJournal of Applied Mathematics
The exchange rate is an important variable in international trade which is used as a parameter to determine a country’s international competitiveness and indicates the position of the country’s economy. A change in the exchange rate of the Kenya shilling
Charline Uwilingiyimana   +3 more
doaj   +1 more source

EPA is Mandating the Normal Distribution

open access: yesStatistics and Public Policy, 2019
The United States Environmental Protection Agency (USEPA) is responsible for overseeing the cleanup of sites that fall within the jurisdiction of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA; also known as “Superfund”)
Steven P. Millard
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

On the Calibration of the Kennedy Model

open access: yesMathematics
The Kennedy model offers a robust framework for modeling forward rates, leveraging Gaussian random fields to accommodate emerging phenomena such as negative rates.
Dalma Tóth-Lakits, Miklós Arató
doaj   +1 more source

Statistical Aspects of High-Dimensional Sparse Artificial Neural Network Models

open access: yesMachine Learning and Knowledge Extraction, 2020
An artificial neural network (ANN) is an automatic way of capturing linear and nonlinear correlations, spatial and other structural dependence among features. This machine performs well in many application areas such as classification and prediction from
Kaixu Yang, Tapabrata Maiti
doaj   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

Delay and Utilization Analysis of Roadside 5G NR IAB Deployments With Half-Duplex Constraints

open access: yesIEEE Open Journal of the Communications Society
The standardized 3GPP integrated access and backhaul (IAB) technology is expected to provide a cost-efficient densification of 5G New Radio access networks. Relying on multi-hop communications, one of the critical metrics in such a system is latency.
Uliana Morozova   +6 more
doaj   +1 more source

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