Results 81 to 90 of about 2,918,183 (286)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Personal probabilities of probabilities [PDF]
Theory and Decision, 1975 By definition, the subjective probability distribution of a random event is revealed by the (‘rational’) subject's choice between bets — a view expressed by F. Ramsey, B. De Finetti, L. J. Savage and traceable to E. Borel and, it can be argued, to T. Bayes.
Jacob Marschak +13 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Journal of Artificial Intelligence Research, 2003 As examples such as the Monty Hall puzzle show, applying conditioning to update a probability distribution on a ``naive space'', which does not take into account the protocol used, can often lead to counterintuitive results. Here we examine why. A criterion known as CAR (``coarsening at random'') in the statistical literature characterizes when ...
Peter Grünwald, Joseph Y. Halpern
openaire +7 more sources
Journal of Probability and Statistics, 2009 Current methods for mapping imprinted quantitative trait locus (iQTL) with inbred line crosses assume fixed QTL effects. When an iQTL segregates in experimental line crosses, combining different line crosses with similar genetic background can improve ...
Gengxin Li, Yuehua Cui
doaj +1 more source
Probability Disassembled [PDF]
, 2006 While there is no universal logic of induction, the probability calculus succeeds as a logic of induction in many contexts through its use of several notions concerning inductive inference. They include Addition, through which low probabilities represent
Norton, JD, Norton, John D.
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
, 2016 It is natural to think that the most basic questions in ethical theory do not have much to do with probability. Given answers to these questions, we can try to extend them to cases involving probability, though this job might best be handled by more ...
David McCarthy +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Large deviation estimates of the crossing probability for pinned Gaussian processes [PDF]
, 2008 The paper deals with the asymptotic behavior of the bridge of a Gaussian process conditioned to stay in it fixed points at n fixed past instants. In particular, functional large deviation results are stated for small time. Several examples are considered:
Caramellino, L +3 more
core +1 more source