Results 61 to 70 of about 1,301,577 (294)

On the Stratonovich Estimator for the Itô Diffusion

open access: yesEuropean Journal of Mathematical Analysis, 2022
For the parameter appearing non-linearly in the drift coefficient of homogeneous Itô stochastic differential equation having a stationary ergodic solution, the paper obtains the strong consistency of an approximate maximum likelihood estimator based on ...
Jaya P. N. Bishwal
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Closed Form Analysis of the Normalized Matched Filter With a Test Case for Detection of Underwater Acoustic Signals

open access: yesIEEE Access, 2016
In this paper, closed-form expressions for the performance of the normalized matched filter (NMF) detector are developed specifically for the case of large time-bandwidth product, N.
Roee Diamant
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Comparing maximum likelihood and maximum pseudolikelihood estimators for the Ising model [PDF]

open access: yesadvances.in/psychology
The Ising model is one of the most popular models in network psychometrics. However, statistical analysis of the Ising model is difficult due to the presence of its intractable normalizing constant in the probability function.
Sara Keetelaar   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated proteins

open access: yesBMC Bioinformatics, 2010
Background Large datasets of protein interactions provide a rich resource for the discovery of Short Linear Motifs (SLiMs) that recur in unrelated proteins. However, existing methods for estimating the probability of motif recurrence may be biased by the
Davey Norman E   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

On Low Treewidth Approximations of Conjunctive Queries [PDF]

open access: yes, 2012
We recently initiated the study of approximations of conjunctive queries within classes that admit tractable query evaluation (with respect to combined complexity).
Libkin, Leonid   +2 more
core  

Home - About - Disclaimer - Privacy