Results 51 to 60 of about 1,301,577 (294)

Local Normal Approximations and Probability Metric Bounds for the Matrix-Variate T Distribution and Its Application to Hotelling’s T Statistic

open access: yesAppliedMath, 2022
In this paper, we develop local expansions for the ratio of the centered matrix-variate T density to the centered matrix-variate normal density with the same covariances.
Frédéric Ouimet
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A Variational Bayes Approach to the Analysis of Occupancy Models. [PDF]

open access: yesPLoS ONE, 2016
Detection-nondetection data are often used to investigate species range dynamics using Bayesian occupancy models which rely on the use of Markov chain Monte Carlo (MCMC) methods to sample from the posterior distribution of the parameters of the model. In
Allan E Clark   +2 more
doaj   +1 more source

Effect of Stop-Loss Reinsurance on Primary Insurer Solvency

open access: yesRisks, 2022
Stop-loss reinsurance is a risk management tool that allows an insurance company to transfer part of their risk to a reinsurance company. Ruin probabilities allow us to measure the effect of stop-loss reinsurance on the solvency of the primary insurer ...
Corina Constantinescu   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

On the uniqueness of probability matching priors [PDF]

open access: yes, 2007
Probability matching priors are priors for which Bayesian and frequentist inference, in the form of posterior quantiles, or confidence intervals, agree to some order of approximation.
Staicu, A-M, Reid, N, Reid, Nancy
core  

Convex approximations for complete integer recourse models [PDF]

open access: yes, 2002
We consider convex approximations of the expected value function of a two-stage integer recourse problem. The convex approximations are obtained by perturbing the distribution of the random right-hand side vector.
Vlerk, Maarten H. van der   +2 more
core   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Approximative Threshold Optimization From Single Antenna to Massive SIMO Authentication

open access: yesIEEE Open Journal of Vehicular Technology, 2023
In a wireless sensor network, data from various sensors are gathered to estimate the system-state of a process system. However, adversaries aim at distorting the estimation, for which they may infiltrate sensors or position additional devices in the ...
Stefan Roth   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

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