Results 41 to 50 of about 384,626 (261)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Fully Pipelined Probability Density Function Engine for Gaussian Copula Model

Tsinghua Science and Technology, 2014
The Gaussian Copula Probability Density Function (PDF) plays an important role in the fields of finance, hydrological modeling, biomedical study, and texture retrieval.
Huabin Ruan, Xiaomeng Huang, Haohuan Fu, Guangwen Yang   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Heuristic Kernel Density Estimator for Modal‑Proximity Data

Shuju Caiji Yu Chuli
Different from the classical probability density estimator construction strategies based on the Parzen window method， we propose a heuristic kernel density estimator （HKDE） based on nearest neighbor error measurement function， to improve the accuracy of ...
HE Yulin, CHEN Chunjia, HUANG Zhexue, LI Junjie, FOURNIER‑VIGER Philippe   +4 more
doaj   +1 more source

Unwrapped Phase Estimation via Normalized Probability Density Function for Multibaseline InSAR

IEEE Access, 2019
Interferometric synthetic aperture radar (InSAR) is a powerful technique for obtaining terrain information based on the interferometric phase. Multibaseline (MB) InSAR is an extension of the conventional InSAR and is used to improve the estimation ...
Huaping Xu, Shuo Li, Yanan You, Aifang Liu, Wei Liu   +4 more
doaj   +1 more source

Convex Optimization on Functionals of Probability Densities [PDF]

, 2020
In information theory, some optimization problems result in convex optimization problems on strictly convex functionals of probability densities.In this note, we study these problems and show conditions of minimizers and the uniqueness of the minimizer if there exist a minimizer.
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Modified Weighted Pareto Distribution Type I (MWPDTI)

مجلة بغداد للعلوم, 2020
In this paper, the Azzallini’s method used to find a weighted distribution derived from the standard Pareto distribution of type I (SPDTI) by inserting the shape parameter (θ) resulting from the above method to cover the period (0, 1] which was neglected
Mahmood A. Sahmran
doaj   +1 more source