Results 51 to 60 of about 176,655 (248)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Adaptive Target Birth Intensity for ET-PHD Filter

MATEC Web of Conferences, 2018
An adaptive tracking algorithm based on Extended target Probability Hypothesis Density (ETPHD) filter is proposed for extended target tracking problem with priori unknown target birth intensity.The algorithm is implemented by gaussian mixture, where the ...
Miao Lu, Feng Xin-xi, Chi Luo-jia
doaj   +1 more source

Multi-Target State Extraction for the SMC-PHD Filter

Sensors, 2016
The sequential Monte Carlo probability hypothesis density (SMC-PHD) filter has been demonstrated to be a favorable method for multi-target tracking.
Weijian Si, Liwei Wang, Zhiyu Qu
doaj   +1 more source

Extended emitter target tracking using GM-PHD filter. [PDF]

PLoS ONE, 2014
If equipped with several radar emitters, a target will produce more than one measurement per time step and is denoted as an extended target. However, due to the requirement of all possible measurement set partitions, the exact probability hypothesis ...
Youqing Zhu, Shilin Zhou, Gui Gao, Huanxin Zou, Lin Lei   +4 more
doaj   +1 more source

Automated neuron tracing using probability hypothesis density filtering [PDF]

Bioinformatics, 2017
Abstract Motivation The functionality of neurons and their role in neuronal networks is tightly connected to the cell morphology. A fundamental problem in many neurobiological studies aiming to unravel this connection is the digital reconstruction of neuronal cell morphology from microscopic image ...
Miroslav Radojevic, Erik Meijering
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Robust Probability Hypothesis Density Filtering: Theory and Algorithms

CoRR
This version is submitted and in review ...
Ming Lei, Shufan Wu
openaire   +2 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Cubature Information SMC-PHD for Multi-Target Tracking

Sensors, 2016
In multi-target tracking, the key problem lies in estimating the number and states of individual targets, in which the challenge is the time-varying multi-target numbers and states.
Zhe Liu, Zulin Wang, Mai Xu
doaj   +1 more source