Results 51 to 60 of about 481,004 (314)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Types of sampling in research

open access: yesJournal of the Practice of Cardiovascular Sciences, 2019
Sampling is one of the most important factors which determines the accuracy of a study. This article review the sampling techniques used in research including Probability sampling techniques, which include simple random sampling, systematic random ...
Pooja Bhardwaj
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Using Inverse Probability Bootstrap Sampling to Eliminate Sample Induced Bias in Model Based Analysis of Unequal Probability Samples.

open access: yesPLoS ONE, 2015
In ecology, as in other research fields, efficient sampling for population estimation often drives sample designs toward unequal probability sampling, such as in stratified sampling.
Matthew Nahorniak   +3 more
doaj   +1 more source

Structural reliability analysis based on a limited directional important sampling simulation

open access: yesNihon Kikai Gakkai ronbunshu, 2015
This study describes an efficient estimation method of the structural failure probability based on a limited directional importance sampling simulation.
Shoya OKUDA, Masaaki YONEZAWA
doaj   +1 more source

On the Determination of Optimum Probabilities in Sampling

open access: yesThe Annals of Mathematical Statistics, 1949
In a previous paper [2] it was shown that it is sometimes profitable to select sampling units with probability proportionate to size of the unit. This note indicates a method of determining the probabilities of selection which minimize the variance of the sample estimate at a fixed cost. Some approximations that have practical applications are given.
Hansen, Morris H., Hurwitz, William N.
openaire   +3 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

WEIGHTING IMPORTANCE SAMPLING METHOD FOR STRUCTURAL TIME-DEPENDENT FAILURE PROBABILITY FUNCTION ESTIMATION

open access: yesJixie qiangdu, 2023
Time-dependent failure probability function(TDFPF) of parameters is one of the key problems of structural time-dependent reliability-based optimization.
QIAN YuGeng, YUAN XiuKai, CHEN JingQiang
doaj  

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