Results 71 to 80 of about 3,700,207 (308)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Reporting on Opinion Polls in the Mass Media: Statement by the 2025-2027 Committee of the European Survey Research Association

Survey Research Methods
The European Survey Research Association (ESRA) has issued a statement expressing concerns over the declining methodological quality of opinion polls and the implications this has on public discourse and democratic processes.
ESRA Committee
doaj   +1 more source

Using Inverse Probability Bootstrap Sampling to Eliminate Sample Induced Bias in Model Based Analysis of Unequal Probability Samples.

PLoS ONE, 2015
In ecology, as in other research fields, efficient sampling for population estimation often drives sample designs toward unequal probability sampling, such as in stratified sampling.
Matthew Nahorniak, David P Larsen, Carol Volk, Chris E Jordan   +3 more
doaj   +1 more source

Structural reliability analysis based on a limited directional important sampling simulation

Nihon Kikai Gakkai ronbunshu, 2015
This study describes an efficient estimation method of the structural failure probability based on a limited directional importance sampling simulation.
Shoya OKUDA, Masaaki YONEZAWA
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

WEIGHTING IMPORTANCE SAMPLING METHOD FOR STRUCTURAL TIME-DEPENDENT FAILURE PROBABILITY FUNCTION ESTIMATION

Jixie qiangdu, 2023
Time-dependent failure probability function(TDFPF) of parameters is one of the key problems of structural time-dependent reliability-based optimization.
QIAN YuGeng, YUAN XiuKai, CHEN JingQiang
doaj  

Importance Sampling in the Evaluation and Optimization of Buffered Failure Probability [PDF]

, 2015
Engineering design is a process in which a system’s parameters are selected such that the system meets certain criteria. These criteria vary in nature and may involve such matters as structural strength, implementation cost, architectural considerations,
Royset, Johannes O., Harajli, Marwan M., R. Tyrrell Rockafellar, Johannes O. Royset, Marwan M. Harajli, Rockafellar, R. Tyrrell   +5 more
core  

Empirical likelihood confidence intervals for complex sampling designs

, 2016
We define an empirical likelihood approach which gives consistent design-based confidence intervals which can be calculated without the need of variance estimates, design effects, resampling, joint inclusion probabilities and linearization, even when the
De La Riva Torres, O., Berger, Y.G.
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Optimising species detection probability and sampling effort in lake fish eDNA surveys [PDF]

Metabarcoding and Metagenomics
Environmental DNA (eDNA) metabarcoding is transforming biodiversity monitoring in aquatic environments. Such an approach has been developed and deployed for monitoring lake fish communities in Great Britain, where the method has repeatedly shown a ...
Graham S. Sellers, Christopher L. Jerde, Lynsey R. Harper, Marco Benucci, Cristina Di Muri, Jianlong Li, Graeme Peirson, Kerry Walsh, Tristan Hatton-Ellis, Willie Duncan, Alistair Duguid, Dave Ottewell, Nigel Willby, Alan Law, Colin W. Bean, Ian J. Winfield, Daniel S. Read, Lori Lawson Handley, Bernd Hänfling   +18 more
doaj   +3 more sources