Results 81 to 90 of about 481,341 (267)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Inference under unequal probability sampling with the Bayesian exponentially tilted empirical likelihood. [PDF]

Biometrika, 2020
Yiu A, Goudie RJB, Tom BDM.
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

ANALYSIS OF CORRESPONDENCE FROM A PROBABILISTIC SAMPLE ANÁLISIS DE CORRESPONDENCIAS A PARTIR DE UNA MUESTRA PROBABILÍSTICA

Revista Colombiana de Estadística, 2010
From the classic analysis of correspondences applied to the denominated tables of correspondences, the theory for this analysis from a probabilistic sample is developed.
Ramírez Javier, Martínez Guillermo
doaj  

An Adaptive Sampling Algorithm with Dynamic Iterative Probability Adjustment Incorporating Positional Information

Entropy
Physics-informed neural networks (PINNs) have garnered widespread use for solving a variety of complex partial differential equations (PDEs). Nevertheless, when addressing certain specific problem types, traditional sampling algorithms still reveal ...
Yanbing Liu, Liping Chen, Yu Chen, Jianwan Ding   +3 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Probabilistic Sampling in Media and Communication Studies: Concept, Procedures, and Applications [PDF]

Eon
This study aims to highlight the vital role of sample selection in media and communication research, as it serves as a fundamental tool for saving time, effort, and resources in data collection and analysis.
Brahim DJENNAD, Mokhtar DJELLOULI
doaj  

Health estimate differences between six independent web surveys: different web surveys, different results?

BMC Medical Research Methodology
Most general population web surveys are based on online panels maintained by commercial survey agencies. Many of these panels are based on non-probability samples. However, survey agencies differ in their panel selection and management strategies. Little
Rainer Schnell, Jonas Klingwort
doaj   +1 more source