Results 151 to 160 of about 18,678 (212)

Transporter-Mediated Interactions Between Uremic Toxins and Drugs: A Hidden Driver of Toxicity in Chronic Kidney Disease. [PDF]

Int J Mol Sci
Spicher P, Brazier F, Laville SM, Liabeuf S, Kamel S, Culot M, Bodeau S.   +6 more
europepmc   +1 more source

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Zidovudine with probenecid

Lancet, The, 1990
AzucenaS. Duckworth, GarrettW. Duckworth, Gary Henderson, Guillermo Contreras   +3 more
exaly   +2 more sources

Naproxen‐probenecid interaction

Clinical Pharmacology & Therapeutics, 1978
Probenecid induced major alterations in the half‐life. renal clearance, and metabolism of naproxen. In 6 healthy subjects who received 500‐mg single oral doses of naproxen alone and (following two days of probenecid loading) with 500 mg of probenecid 4 times a day, there was an increase in naproxen plasma half‐life from the normal 14 to 37 hr.
R, Runkel, E, Mroszczak, M, Chaplin, H, Sevelius, E, Segre   +4 more
openaire   +2 more sources

Probenecid-clofibrate interaction

Clinical Pharmacology and Therapeutics, 1981
Clofibric acid disposition was studied in four healthy men after 1 wk of clofibrate ingestion (500 mg orally every 12 hr) with and without probenecid (500 mg orally every 6 hr). Mean (+/- SD) free clofibric acid plasma concentration in the four subjects over a dosage interval at steady state was 2.5 +/- 0.03 mg/1 before and 9.05 +/- 1.09 mg/1 after the
J R, Veenendaal, P M, Brooks, P J, Meffin   +2 more
openaire   +2 more sources

Clinical Pharmacokinetics of Probenecid

Clinical Pharmacokinetics, 1981
A review of the clinical applications and of the disposition of probenecid in man, including drug interactions, is presented. Probenecid is the classical competitive inhibitor of organic acid transport in the kidney and other organs. There are 2 primary clinical uses for probenecid: as a uricosuric agent in the treatment of chronic gout and as an ...
R F, Cunningham, Z H, Israili, P G, Dayton   +2 more
openaire   +2 more sources

A Death Involving Probenecid

Journal of Forensic Sciences, 1992
Abstract A death following deliberate ingestion of approximately 75 g of probenecid in a 36-year-old man is described. Tissue concentrations of probenecid were highest in serum (710 mg/L) and liver (550 mg/kg). Probenecid was also detected in vitreous and bile. Ethanol was also detected in blood at 0.13 g/100 mL.
I M, McIntyre, K, Crump, A N, Roberts, O H, Drummer   +3 more
openaire   +2 more sources