Results 51 to 60 of about 4,574,423 (281)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Finding Two Disjoint Simple Paths on Two Sets of Points is NP-Complete
, 2017 Finding two disjoint simple paths on two given sets of points is a geometric problem introduced by Jeff Erickson. This problem has various applications in computational geometry, like robot motion planning, generating polygon etc.
Razzazi, Mohammadreza +1 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
PMS5: an efficient exact algorithm for the (ℓ,
BMC Bioinformatics, 2011 Background Motifs are patterns found in biological sequences that are vital for understanding gene function, human disease, drug design, etc. They are helpful in finding transcriptional regulatory elements, transcription factor binding sites, and so on ...
Dinh Hieu +2 more
doaj +1 more source
, 2017 In this paper, we consider the problem of finding a maximum cardinality subset of vectors, given a constraint on the normalized squared length of vectors sum. This problem is closely related to Problem 1 from (Eremeev, Kel'manov, Pyatkin, 2016). The main
AA Ageev +8 more
core +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Random Costs in Combinatorial Optimization
, 1999 The random cost problem is the problem of finding the minimum in an exponentially long list of random numbers. By definition, this problem cannot be solved faster than by exhaustive search.
B. Derrida +22 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
SITUATION-BASED LEARNING UNTUK MENINGKATAN KEMAMPUAN CREATIVE PROBLEM SOLVING MATEMATIS SISWA SD
Mimbar Sekolah Dasar, 2014 In general, the learning activity that occurs is more emphasis on the process of learning to learn to answer questions rather than learn how to present the question.
Isrok’atun Isrok’atun +1 more
doaj +1 more source