Results 61 to 70 of about 2,052,150 (308)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Mobile Phone Craving in Spain: Associations with Impulsivity, Anxiety, Gaming Problem, and Gambling Severity

Behavioral Sciences
Craving for mobile phone use is increasingly discussed as a relevant feature of problematic engagement with digital technologies. This population-based study of 1601 Spanish adults examined psychological factors (impulsivity traits and affective symptoms)
Jose de-Sola, Joan I. Mestre-Pintó, Víctor José Villanueva-Blasco, Hernán Talledo, Antonia Serrano, Gabriel Rubio, Fernando Rodríguez de Fonseca   +6 more
doaj   +1 more source

Problematic Mobile Phone and Smartphone Use Scales: A Systematic Review

Frontiers in Psychology, 2020
The popularity of smartphones is undeniable in nearly all facets of society. Despite the many benefits attributed to the technology, concern has grown over the potential for excessive smartphone use to become problematic in nature.
Bethany Harris, Timothy Regan, Jordan Schueler, Sherecce A. Fields   +3 more
doaj   +1 more source

The relationship between difficulties in emotion regulation and dysfunctional technology use among adolescents [PDF]

, 2019
Objectives Since two decades scientific research is studying excessive and dysfunctional new technologies use and its influences on people’s lives, in terms of personal, relational, scholastic and work functioning impairment.
Amendola, Simone, Cerutti, Rita, Guidetti, Vincenzo, Spensieri, Valentina   +3 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Family strains and online gains: Longitudinal relationship between harsh parenting and problematic internet use via relative deprivation and online basic psychological need satisfaction

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
Harsh parenting has been demonstrated as a risk factor for adolescent problematic internet use (PIU), while its relationships with distinct subtypes of PIU have been scarcely investigated.
Zongyuan Wang, Qinxue Liu, Zien Ding, Di Qi   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Regular and problematic leisure-time Internet use in the community: results from a German population-based survey [PDF]

, 2010
In our study, we attempted to identify systematically the use of Internet applications in the German population in order to derive risk factors for problematic use. In a representative survey of the German population, we queried 1,401 women and 1,111 men
Beutel, ME, Brähler, E, Glaesmer, H, Kuss, DJ, Müller, KW, Wölfling, K   +5 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source