Chemical Engineering Transactions, 2019 Alzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing number of people around the world. Due to the adverse effects caused by drugs for treating this disease currently in clinical use, it is necessary to ...
Geane Oliveira +4 more
doaj +1 more source
Diagnosis and management of junctional ectopic tachycardia in children
Annals of Pediatric Cardiology, 2021 Junctional ectopic tachycardia (JET) is more common in its postoperative form. A thorough understanding of its etiology, pathophysiology, and management strategies is essential.
Navaneetha Sasikumar +2 more
doaj +1 more source
771-4 Enhancement of Delayed Afterdepolarlzatlons (DADs) and Triggered Activity by E-4031 and Dofetilide In a Cardiac Glycoside Model of Cell Ca2+ Overload [PDF]
, 1995 HypothesisSeveral new class III antiarrhythmic drugs, including E-4031 and Dofetilide. are reported to selectively block the rapidly activating delayed rectifier current (iKR).
Cunningham, Peter M. +2 more
core +1 more source
Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction.
Acta Médica Portuguesa, 1980 Using Holter recordings and based on the principle that most of the survivors of acute myocardial infarction who are going to die suddenly after hospital discharge are those who present ventricular premature beats (VPB), the authors have studied the ...
J. L. Tuna +5 more
doaj +3 more sources
Epigenetically Altered T Cells Contribute to Lupus Flares
Cells, 2019 Lupus flares when genetically predisposed people encounter exogenous agents such as infections and sun exposure and drugs such as procainamide and hydralazine, but the mechanisms by which these agents trigger the flares has been unclear. Current evidence
Bruce Richardson
doaj +1 more source
Arrhythmogenic drugs can amplify spatial heterogeneities in the electrical restitution in perfused guinea-pig heart: An evidence from assessments of monophasic action potential durations and JT intervals. [PDF]
PLoS ONE, 2018 Non-uniform shortening of the action potential duration (APD90) in different myocardial regions upon heart rate acceleration can set abnormal repolarization gradients and promote arrhythmia.
Oleg E Osadchii
doaj +1 more source
Pharmacology and relevant drug interactions of metamizole
British Journal of Clinical Pharmacology, EarlyView.Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman +3 more
wiley +1 more source
Effect of voltage-gated sodium channels blockers on motility and viability of human sperm in vitro
Asian Pacific Journal of Reproduction, 2018 Objective: To test the effect of voltage-gated sodium channels (VGSCs) blockers on the motility and viability of human sperm in-vitro and to evaluate the tested compounds as potential contact spermicidal.Methods: Sperm samples were obtained from healthy ...
Hammad Ahmad Gakhar +3 more
doaj +1 more source
Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle [PDF]
, 1999 Objective: To study the interaction between salicylate and class 1 antiarrhythmic agents. Methods: The effects of salicylate on class 1 antiarrhythmic agent-induced tonic and phasic block of the Na+ current (INa) of ventricular myocytes and the upstroke ...
Hisatome, Ichiro +13 more
core +1 more source