Results 191 to 200 of about 3,907,042 (354)

Impact of Esophageal Temperature Monitoring on Esophageal Injury in PVI: A Systematic Review and Meta-Analysis. [PDF]

Ann Noninvasive Electrocardiol
Manzoor S, Kotte M, Malik J, Singla B, Singla S, Subhan M, Sandesh F, Kumari P, Ashraf A, Perveen A.   +9 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Increased Aortic Angulation in Transcatheter Aortic Valve Implantation-Still a Challenging Anatomy? [PDF]

Interdiscip Cardiovasc Thorac Surg
Polat E, Fortunato A, Schemet L, Friedrich-Welz S, Tomsic A, Amer M, Girdauskas E, Owais T.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Sequential Human Assembly and Disassembly Motions in Human-Robot Coexisting Environments. [PDF]

Sci Data
Liu Z, Wang T, Ji Z, Xu W, Wang L, Wang XV.   +5 more
europepmc   +1 more source

A generalized framework for procedural generation of three-dimensional static and dynamic plant model geometries [PDF]

Brian N. Bailey
openalex  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Small Nodules and Big Questions: A Closer Look at the RELIANT Trial. [PDF]

Am J Respir Crit Care Med
Bertolaccini L, Bardoni C, Guarize J.
europepmc   +1 more source

Dynamic Difficulty Adjustment in 2D Platformers through Agent-Based Procedural Level Generation

, 2015
Daniel Wheat, Martin Mašek, Chiou Peng Lam, Philip Hingston   +3 more
openalex   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source