Results 141 to 150 of about 1,503,003 (262)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A plan to transform primary and community care at Catalonia based on a process improvement methodology. [PDF]

Prim Health Care Res Dev
Sales Coll M, Manjón S, Salabert J, Pladevall C, Algar D, Benaque A, Soler J, Ochoa de Echagüen Aguilar A.   +7 more
europepmc   +1 more source

Production of Gluconic Acid and Its Derivatives by Microbial Fermentation: Process Improvement Based on Integrated Routes. [PDF]

Front Bioeng Biotechnol, 2022
Ma Y, Li B, Zhang X, Wang C, Chen W.
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

New insights on poly(<i>cis</i>-1,4-isoprene) rubber degradation through enzymatic kinetics and process improvement. [PDF]

Front Bioeng Biotechnol
Guajardo-Flores C, Rojas J, Baldera-Moreno Y, Adasme-Carreño F, Kasai D, Andler R.   +5 more
europepmc   +1 more source

An initiative to improve effluent culture detection among pediatric patients undergoing peritoneal dialysis through process improvement. [PDF]

Pediatr Nephrol, 2023
Pangonis SF, Schaffzin JK, Claes D, Mortenson JE, Nehus E.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Increasing and sustaining discharges by noon - a multi-year process improvement project. [PDF]

BMC Health Serv Res
Bailey R, Segon A, Garcia S, Kottewar S, Lu T, Tuazon N, Sanchez L, Gelfond JA, Bowling G.   +8 more
europepmc   +1 more source

Elderly trauma mortality in a resource-limited setting: A benchmark for process improvement. [PDF]

Injury, 2021
Williams BM, Kayange L, Purcell L, Charles A, Gallaher J.   +4 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source