Results 81 to 90 of about 2,983,030 (287)

Living labs for in-situ open innovation: from idea to product validation and beyond [PDF]

, 2014
In this paper we present the Living Lab methodology as an overall framework for in-situ open innovation involving the end-user as equal participant in the innovation process.
Baccarne, Bastiaan, Coorevits, Lynn, De Meulenaere, Jonas, Georges, Annabel, Lievens, Bram, Schuurman, Dimitri, Vandenbroucke, Karel   +6 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Effects of Omega-3 Supplementation on the Omega-3 Index and Quality of Life and Pain Scores in Dogs

Animals
This study in dogs had two objectives: first, to determine whether a daily supplement of marine omega-3 (EPA and DHA) would (1) increase red blood cell EPA + DHA levels (i.e., the Omega-3 Index derived from dried blood spot analysis) and (2) impact ...
Carolina Carlisle, Brandon T. Metzger, Nathan L. Tintle, Kristine Polley, Kristina H. Jackson, Sara Le Brun-Blashka, Jody Griffiths, William S. Harris   +7 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

"I'm stressed!": The work effect of process innovation on mental health. [PDF]

SSM Popul Health, 2023
Du Y, Shahiri H, Wei X.
europepmc   +1 more source

Unlocking the potential of trace cobalt in Ni-based superalloys: A molecular dynamics study on dislocation behavior and high-temperature stability

Materials & Design
Cobalt (Co) is one of the fastest diffusing elements in Nickel (Ni)-based single crystal superalloys, playing a critical role in stabilizing the γ matrix and γ′ precipitate, and influencing dislocation behavior and deformation mechanisms.
Huicong Dong, Yinghao Chen, Dayong Wu, Haikun Ma, Zhihao Feng, Ru Su   +5 more
doaj   +1 more source

Product and process innovation and the decision to export : firm-level evidence for Belgium [PDF]

Using data from the Community Innovation Survey for Belgium in two consecutive periods, this paper explores the relationship between firm-level innovation activities and the propensity to start exporting.
VAN BEVEREN, Ilke, VANDENBUSSCHE, Hylke
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Digital Processes for the Redevelopment of Social Housing in Plattenbau

Agathón, 2019
As part of a framework agreement between the DiARC of the ‘Federico II’ University of Naples and the Fakultät Bauwesen of the HTWK Leipzig, which led to a collaboration with the LWB – the public housing manager of the city of Leipzig which for years has ...
Marina Block, Massimo Perriccioli, Monica Rossi-Schwarzenbeck   +2 more
doaj   +1 more source