Results 91 to 100 of about 2,207,660 (295)
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
$B \to X_{s} \tau^{+} \tau^{-}$ in the flipped SU(5) model
We perform a detailed study of the inclusive branching ratio and the forward-backward asymmetry of the rare B decay process $B \longrightarrow X_{s} \tau^{+} \tau^{-}$ in the flipped SU(5) model, a predictive model which has only two free parameters ...
Barbieri +13 more
core +1 more source
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Bistable Smart Window Based on Ionic Liquid Doped Cholesteric Liquid Crystal
We develop a bistable smart window based on mixture of negative dielectric nematic liquid crystal, chiral dopant, and chiral ionic liquid (CIL). The developed smart window is driven by dual-frequency modulation, where the transparent state is turned on ...
Zhaojue Lan +3 more
doaj +1 more source
Molecular cancer prevention: Intercepting disease
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
To enhance stability during the forming process and improve the quality of the product, it is essential to analyze and identify the influence of the process parameters on the sheet formability.
Adil Sh. Jaber +2 more
doaj +1 more source
Experimental Development of an Injection Molding Process Window. [PDF]
Myers M +3 more
europepmc +1 more source
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source

