Results 91 to 100 of about 84,402,451 (356)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Lower bounds for multi-pass processing of multiple data streams [PDF]

, 2009
This paper gives a brief overview of computation models for data stream processing, and it introduces a new model for multi-pass processing of multiple streams, the so-called mp2s-automata.
Schweikardt, Nicole
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

From Processing-in-Memory to Processing-in-Storage

Supercomputing Frontiers and Innovations, 2017
Near-data in-memory processing research has been gaining momentum in recent years. Typical processing-in-memory architecture places a single or several processing elements next to a volatile memory, enabling processing without transferring data to the host CPU. The increased bandwidth to and from volatile memory leads to performance gain.
Roman Kaplan, Leonid Yavits, Ran Ginosar
openaire   +1 more source

Diffusion in disordered media as a process with memory [PDF]

Physical Review E, 1996
The problem of a random walk in a disordered media is mapped into a model of a random walk with memory. The latter model, as opposed to the former one, does not make reference to a particular realization of the disorder. The equivalence of the two models implies that the new model retrieves dynamically a realization of disorder; the only one which is ...
Vendruscolo, Michele, Marsili, Matteo
openaire   +3 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Evaluating Energy Efficiency of Genomics Algorithms on Processing-in-Memory Architectures

International audienceProcessing-in-Memory (PiM) is a novel computing paradigm for reducing data movements between memory and processing units, and thus minimizing energy consumption.
Drezen, Erwan, de Moor, Florestan, Falevoz, Yann, Mognol, Meven, Lavenier, Dominique   +4 more
core   +2 more sources

SpDRAM: Efficient In-DRAM Acceleration of Sparse Matrix-Vector Multiplication

IEEE Access
We introduce novel sparsity-aware in-DRAM matrix mapping techniques and a corresponding DRAM-based acceleration framework, termed SpDRAM, which utilizes a triple row activation scheme to efficiently handle sparse matrix-vector multiplication (SpMV).
Jieui Kang, Soeun Choi, Eunjin Lee, Jaehyeong Sim   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source