Results 71 to 80 of about 4,839,172 (251)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Journal of Pharmacy and Bioallied SciencesBackground: Brain training games refer to as the activities designed for the stimulation of several cognitive functions. These games could be carried out through different platforms and can be accessed through smart phones, tablets, computers and other ...
Fahad Somaa, Azka Khan, Alaa Arafah
doaj +1 more source
Frontiers in Aging Neuroscience, 2019 Age-related differences in white matter (WM) microstructure have been linked to lower performance in tasks of processing speed in healthy older individuals. However, only few studies have examined this link in a longitudinal setting. These investigations
Jessica Oschwald +7 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Spatial attention shifting and phonological processing in adults with dyslexia [PDF]
, 2015 According to Hari and Renvall’s (2001) sluggish attentional shifting (SAS) hypothesis people with dyslexia have a central deficit in attention shifting.
Larkin, RF, Abbott, I, Dunn, AK
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Characterizing Cognitive Aging in Humans with Links to Animal Models
Frontiers in Aging Neuroscience, 2012 With the population of older adults expected to grow rapidly over the next two decades, it has become increasingly important to advance research efforts to elucidate the mechanisms associated with cognitive aging, with the ultimate goal of developing ...
Gene E Alexander +15 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
High Speed Blanking: An Experimental Method to Measure Induced Cutting Forces [PDF]
, 2013 Lien vers la version éditeur: http://link.springer.com/article/10.1007/s11340-013-9738-1A new blanking process that involves punch speed up to 10 ms −1 has obvious advantages in increased productivity.
LARUE, Arnaud +5 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source