Results 101 to 110 of about 149,979,910 (297)
Sophie Doulut, "From the Barbican to the Colony"
On English Plymouth harbour, there’s a gateway, The sky is framed within an invisible door Seagulls flitter through it and away, The way the Pilgrim Fathers walked through it before. A few yards away, the list of passengers reads On the stone walls of
The LOOP team
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Processor-in-the-loop Development System for e200 Core Microcontrollers [PDF]
Hlavní cíl této diplomové práce je vytvořit processor-in-the-loop systém založený na mikrokontroléru od firmy NXP s jádrem e200 - MPC5748G. Použití vizuálních programovacích nástrojů, například Simulink, umožňuje využití principu Model-Based Design během
Albershteyn Andrey
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Sophie Doulut, Let the Souls Out
Aboard the ship of bad omen headed to Toronto, The tired and poor Irish crowds travel huddled together, A dark agony in the hold of the gloomy and eerie cargo Where all Catholics and Protestants agree to surrender.
The LOOP team
core +1 more source
Sophie Doulut, "Aladdin's Tree"
, 2023 Along the road stand crepe myrtles Bearing grapes of flowers Like so many jewels Gems of the sun and earth wed together. Their bright and vivid colors Light up the path of humans Who walk demurely and coyly Underneath them, Ignoring ...
The LOOP team
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source