Results 41 to 50 of about 41,499 (247)
Advanced Science, EarlyView.This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer +17 more
wiley +1 more source
Renaturation of disulfide‐linked procollagen [PDF]
Journal of Supramolecular Structure, 1974 AbstractDisulfide‐linked, triple‐stranded procollagen (pro γ 112) was isolated from chick embryo skull bones. It was reversibly denatured and renatured as judged by sedimentation properties and susceptibility to digestion with pepsin. Refolding was an intramolecular process and aggregation between molecules did not occur.
L I, Fessler, C, Rudd, J H, Fessler
openaire +2 more sources
Procollagen Lysyl Hydroxylase 2 is Essential for Hypoxia-Induced Breast Cancer Metastasis
Molecular Cancer Research, 2013 Metastasis is the leading cause of death among patients who have breast cancer. Understanding the role of the extracellular matrix (ECM) in the metastatic process may lead to the development of improved therapies to treat patients with cancer ...
Daniele M. Gilkes +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source
A molecular ensemble in the rER for procollagen maturation.
Biochimica et Biophysica Acta, 2013 Extracellular matrix (ECM) proteins create structural frameworks in tissues such as bone, skin, tendon and cartilage etc. These connective tissues play important roles in the development and homeostasis of organs.
Y. Ishikawa, H. Bächinger
semanticscholar +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Study of collagen type III and VI remodeling as a potential biomarker for disease activity in systemic lupus patients with lupus nephritis [PDF]
Romanian Journal of RheumatologyObjectives. This study aimed to evaluate collagen type III and VI remodeling biomarkers as a possible indicator of disease activity in patients with lupus nephritis (LN). Materials and methods.
Eman Ebrahim Salaheldeen Mohamed +4 more
doaj +1 more source
Dasatinib Attenuates Fibrosis in Keloids by Decreasing Senescent Cell Burden
Acta Dermato-Venereologica, 2023 Keloids are skin tumours caused by aberrant growth of dermal fibroblasts. Cellular senescence contributes to aging and various pathological conditions, including cancer, atherosclerosis, and fibrotic diseases.
Claudia C. Darmawan +5 more
doaj +1 more source
THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome
Advanced Science, EarlyView.The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong +16 more
wiley +1 more source
Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Advanced Science, EarlyView.This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang +7 more
wiley +1 more source