Results 21 to 30 of about 41,499 (247)
Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. [PDF]
PLoS ONE, 2014 The proprotein convertase site-1 protease (S1P) converts latent ER-membrane bound transcription factors SREBPs and ATF6 to their active forms. SREBPs are involved in cholesterol and fatty acid homeostasis whereas ATF6 is involved in unfolded protein ...
Debabrata Patra +3 more
doaj +1 more source
Role of procollagen mRNA levels in controlling the rate of procollagen synthesis. [PDF]
Molecular and Cellular Biology, 1983 Two factors must be present for primary avian tendon cells to commit 50% of their total protein production to procollagen: ascorbate and high cell density. Scorbutic primary avian tendon cells at high cell density (greater than 4 X 10(4) cells per cm2) responded to the addition of ascorbate by a sixfold increase in the rate of procollagen synthesis ...
Rowe, L B, Schwarz, R I
openaire +2 more sources
Translational Neuroscience, 2016 A possible relationship between fibrosis along the route of cerebrospinal fluid (CSF) flow and the subsequent development of hydrocephalus has been indicated in previous studies.
Hao Xu +8 more
doaj +1 more source
PLoS Genetics, 2021 Heat shock protein 47 (HSP47), encoded by the SERPINH1 gene, is a molecular chaperone essential for correct folding of collagens. We report a homozygous p.(R222S) substitution in HSP47 in a child with severe osteogenesis imperfecta leading to early ...
Delfien Syx +12 more
doaj +1 more source
Fibronectin matrix as a scaffold for procollagen proteinase binding and collagen processing
Molecular Biology of the Cell, 2019 The extracellular matrix (ECM) proteins fibronectin (FN) and type I collagen (collagen I) are codistributed in many tissues, and collagens have been shown to depend on an FN matrix for fibrillogenesis.
Jared T Saunders, J. Schwarzbauer
semanticscholar +1 more source
ER-to-Golgi trafficking of procollagen in the absence of large carriers
bioRxiv, 2018 Secretion and assembly of collagen is fundamental to the function of the extracellular matrix. Defects in the assembly of a collagen matrix lead to pathologies including fibrosis and osteogenesis imperfecta.
Janine McCaughey +3 more
semanticscholar +1 more source
COPII-coated membranes function as transport carriers of intracellular procollagen I
bioRxiv, 2017 The coat protein complex II (COPII) is essential for the secretion of large cargo, such as the 300 nm precursor fibrils of procollagen I (PC1). Previous work has shown that the CUL3-KLHL12 complex increases the size of COPII vesicles to over 300 nm in ...
A. Gorur +5 more
semanticscholar +1 more source
Health Science Reports, 2023 Background and Aims Arthrofibrosis is a severe scarring condition characterized by joint stiffness and pain. Fundamental to developing arthrofibrotic scars is the accelerated production of procollagen I, a precursor of collagen I molecules that form ...
Benjamin A. Hendy +5 more
doaj +1 more source
Journal of Bone and Mineral Research, 2016 Glycine (Gly) substitutions in collagen Gly‐X‐Y repeats disrupt folding of type I procollagen triple helix and cause severe bone fragility and malformations (osteogenesis imperfecta [OI]).
Lynn S. Mirigian +7 more
semanticscholar +1 more source
PLoS ONE, 2014 UnlabelledHepatic stellate cell (HSC) activation is an essential event during alcoholic liver fibrosis. Evidence suggests that adenosine aggravates liver fibrosis via the adenosine A2A receptor (A2AR).
He Wang +7 more
doaj +1 more source