Results 11 to 20 of about 41,499 (247)
ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts
Advanced Science, 2022 Cellular response to protein misfolding underlies multiple diseases. Collagens are the most abundant vertebrate proteins, yet little is known about cellular response to misfolding of their procollagen precursors.
Laura Gorrell +4 more
doaj +2 more sources
TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export
eLife, 2015 Previously we showed that membrane fusion is required for TANGO1-dependent export of procollagen VII from the endoplasmic reticulum (ER) (Nogueira, et al., 2014).
António JM Santos +4 more
doaj +2 more sources
eLife, 2014 TANGO1 binds and exports Procollagen VII from the endoplasmic reticulum (ER). In this study, we report a connection between the cytoplasmic domain of TANGO1 and SLY1, a protein that is required for membrane fusion.
Cristina Nogueira +6 more
doaj +2 more sources
Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1 [PDF]
Structure, 2018 Procollagen C-proteinase enhancer-1 (PCPE-1) is a secreted protein that specifically accelerates proteolytic release of the C-propeptides from fibrillar procollagens, a crucial step in fibril assembly. As such, it is a potential therapeutic target to improve tissue repair and prevent fibrosis, a major cause of mortality worldwide.
Pulido, D +10 more
openaire +5 more sources
Mechanisms of procollagen and HSP47 sorting during ER-to-Golgi trafficking
Matrix Biology, 2020 Efficient quality control and export of procollagen from the cell is crucial for extracellular matrix homeostasis, yet it is still incompletely understood.
S. Omari +5 more
semanticscholar +1 more source
Biosynthesis of Cartilage Procollagen [PDF]
European Journal of Biochemistry, 1973 Cells were isolated by controlled enzymic digestion of sternal cartilages from chick embryos and the cells were studied immediately after isolation for up to 4 h in vitro. The cells isolated under the conditions employed had a high degree of viability, they remained in suspension for 2 to 4 h in vitro and during this time they synthesized and secreted ...
P, Dehm, D J, Prockop
openaire +2 more sources
Matrix Biology Plus, 2023 Type II collagen is the major fibrillar collagen in cartilage. It is synthesized in the form of precursors (procollagens) containing N- and C-terminal propeptides.
Emeline Perrier-Groult +5 more
doaj +1 more source
A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex
EMBO Journal, 2018 Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are synthesized in the endoplasmic reticulum (ER), and a fraction that fails to ...
A. Forrester +18 more
semanticscholar +1 more source
Matrix Biology Plus, 2021 For next generation tissue-engineered constructs and regenerative medicine to succeed clinically, the basic biology and extracellular matrix composition of tissues that these repair techniques seek to restore have to be fully determined. Using the latest
Audrey McAlinden +4 more
doaj +1 more source
浙江大学学报. 农业与生命科学版, 2005 Cultured fibroblasts were exposed to 585-nm flashlamp-pumped pulsed dye laser (fluence 3 J/cm2, 5 J/cm2,7 J/cm2, spot size 7 mm, pulse duration 450 μs) followed by 24 h incubation.
YU Hai-yan +3 more
doaj +1 more source