Results 1 to 10 of about 41,499 (247)

Does type 2 diabetes affect bone metabolism in patients after hip fracture? A case–control study [PDF]

Journal of International Medical Research
Objective This study aimed to compare bone metabolism markers between patients with hip fracture who had and did not have type 2 diabetes mellitus (T2DM).
Shaofeng Yang, Pengrui Jing, Bin Meng, Fanqi Kong   +3 more
doaj   +2 more sources

SCYL1 deficiency in CALFAN syndrome is associated with ER stress and cell death [PDF]

Disease Models & Mechanisms
John Hellicar, Tal Dattner, Tian Sun, Lily Percival, Ruby Chrisp, Andrea Pietrobattista, Tomasz Witkos, Aleksander Mironov, Lina Leghlam, Carolin Jentsch, Stefan Koelker, Georg F. Hoffmann, Christian Staufner, Wanjin Hong, Dominic Lenz, Martin Lowe   +15 more
doaj   +2 more sources

Higher Levels of Plasma Hyaluronic Acid and N-terminal Propeptide of Type III Procollagen Are Associated With Lower Kidney Function in Children With Non-alcoholic Fatty Liver Disease

Frontiers in Pediatrics, 2022
ObjectiveHyaluronic acid (HA) and N-terminal propeptide of type III procollagen (PIIINP) are two non-invasive biomarkers of liver fibrosis in non-alcoholic fatty liver disease (NAFLD).
Antonella Mosca, Alessandro Mantovani, Annalisa Crudele, Nadia Panera, Donatella Comparcola, Rita De Vito, Marzia Bianchi, Christopher D. Byrne, Christopher D. Byrne, Giovanni Targher, Anna Alisi   +10 more
doaj   +1 more source

Second‐trimester amniotic fluid proteins changes in subsequent spontaneous preterm birth

Acta Obstetricia et Gynecologica Scandinavica, 2023
Introduction The global sequence of the pathogenesis of preterm labor remains unclear. This study aimed to compare amniotic fluid concentrations of extracellular matrix‐related proteins (procollagen, osteopontin and IL‐33), and of cytokines (IL‐19, IL‐6,
Louis Marcellin, Frédéric Batteux, Sandrine Chouzenoux, Thomas Schmitz, Elsa Lorthe, Céline Mehats, François Goffinet, Gilles Kayem   +7 more
doaj   +1 more source

Imaging of type I procollagen biosynthesis in cells reveals biogenesis in highly organized bodies; Collagenosomes

Matrix Biology Plus, 2021
Mechanistic aspects of type I procollagen biosynthesis in cells are poorly understood. To provide more insight into this process we designed a system to directly image type I procollagen biogenesis by co-expression of fluorescently labeled full size ...
Branko Stefanovic, Lela Stefanovic, Zarko Manojlovic   +2 more
doaj   +1 more source

Visualized procollagen Iα1 demonstrates the intracellular processing of propeptides

Life Science Alliance, 2022
Procollagen Iα1 with two tags reveals the different fates of processed propeptides, the rate-limiting step in collagen secretion, and a link between defects in intracellular processing and diseases.
Toshiaki Tanaka, Koji Moriya, Makoto Tsunenaga, Takayo Yanagawa, Hiromi Morita, Takashi Minowa, Yoh-ichi Tagawa, Nobutaka Hanagata, Yutaka Inagaki, Toshiyuki Ikoma   +9 more
doaj   +1 more source

Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen [PDF]

Proceedings of the National Academy of Sciences, 1971
A heritable connective tissue disorder of cattle, dermatosparaxis, is characterized by an extreme fragility of the skin and the presence of additional peptides at the N-terminal extremities of the collagen α chains, p-α 1 and p-α 2 .
C M, Lapière, A, Lenaers, L D, Kohn
openaire   +2 more sources

Silver Nanoparticles Alter Cell Viability Ex Vivo and in Vitro and Induce Proinflammatory Effects in Human Lung Fibroblasts

Nanomaterials, 2020
Silver nanoparticles (AgNPs) are commonly used in commercial and medical applications. However, AgNPs may induce toxicity, extracellular matrix (ECM) changes and inflammatory responses.
Anna Löfdahl, Andreas Jern, Samuel Flyman, Monica Kåredal, Hanna L Karlsson, Anna-Karin Larsson-Callerfelt   +5 more
doaj   +1 more source

Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice

Hepatology Communications, 2022
Hepatic fibrosis is driven by deposition of matrix proteins following liver injury. Hepatic stellate cells (HSCs) drive fibrogenesis, producing matrix proteins, including procollagen I, which matures into collagen I following secretion.
Samuel C. Buchl, Zachary Hanquier, Andrew J. Haak, Yvonne M. Thomason, Robert C. Huebert, Vijay H. Shah, Jessica L. Maiers   +6 more
doaj   +1 more source

Therapeutic Effects of 17β-Estradiol on Pelvic Organ Prolapse by Inhibiting Mfn2 Expression: An In Vitro Study

Frontiers in Endocrinology, 2020
ObjectiveTo assess the effects of 17β-estradiol (E2) on proliferation, apoptosis, and protein expressions of fibroblasts at different concentrations and time intervals to reveal the mechanism of E2 in the treatment of pelvic organ prolapse (POP).Study ...
Xiao-Qing Wang, Rui-Ju He, Bing-Bing Xiao, Ye Lu   +3 more
doaj   +1 more source