Results 31 to 40 of about 41,499 (247)

The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.

Matrix Biology, 2015
Collagen fibers are the main components of most of the extracellular matrices where they provide a structural support to cells, tissues and organs. Fibril-forming procollagens are synthetized as individual chains that associate to form homo- or hetero ...
M. Bekhouche, A. Colige
semanticscholar   +1 more source

Lentinula edodes extract inhibits matrix metalloproteinase expression and increases type I procollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To determine the effect of Lentinula edodes extract on ultraviolet (UV) A and UVB-induced changes in matrix metalloproteinase (MMP) and type I procollagen expression using human immortalized HaCaT keratinocytes.
Jung Im Lee, Jung Hwan Oh, Fatih Karadeniz, So Young Park, Hye Ran Kim, Hyun Jin Jo, Kyung Im Jung, Byung-Jin Jeon, Chang-Suk Kong   +8 more
doaj   +1 more source

Specific hepatic delivery of procollagen α1(I) siRNA in lipid-like nanoparticles resolves liver fibrosis

Hepatology, 2015
Fibrosis accompanies the wound‐healing response to chronic liver injury and is characterized by excessive hepatic collagen accumulation dominated by collagen type I. Fibrosis often progresses to cirrhosis. Here we present in vivo evidence of an up to 90%
C. J. Calvente, A. Sehgal, Y. Popov, Yong Ook Kim, V. Zevallos, U. Şahin, M. Diken, D. Schuppan   +7 more
semanticscholar   +1 more source

Data comparing the kinetics of procollagen type I processing by bone morphogenetic protein 1 (BMP-1) with and without procollagen C-proteinase enhancer 1 (PCPE-1)

Data in Brief, 2016
This article provides kinetic constants for C-terminal processing of procollagen type I by bone morphogenetic protein 1 (BMP-1; the major procollagen C-proteinase), a reaction stimulated by the connective tissue glycoprotein procollagen C-proteinase ...
Laura Moschcovich, Efrat Kessler
doaj   +1 more source

Atrial Tissue Pro‐Fibrotic M2 Macrophage Marker CD163+, Gene Expression of Procollagen and B‐Type Natriuretic Peptide

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Atrial tissue fibrosis is linked to inflammatory cells, yet is incompletely understood. A growing body of literature associates peripheral blood levels of the antifibrotic hormone BNP (B‐type natriuretic peptide) with atrial fibrillation (AF).
Chris J. Watson, Nadezhda Glezeva, Stephen Horgan, Joe Gallagher, Dermot Phelan, Ken McDonald, Michael Tolan, John Baugh, Patrick Collier, Mark Ledwidge   +9 more
doaj   +1 more source

Jatrorrhizine Isolated from Phellodendron amurense Improves Collagen Homeostasis in CCD-986sk Human Dermal Fibroblast Cells

Cosmetics
Jatrorrhizine is one of the major bioactive compounds found in Phellodendron amurense. Previous studies have reported various health benefits of jatrorrhizine, but little is known about its effect on skin health.
Junhyo Cho
doaj   +1 more source

Structural implications from an electronmicroscopic comparison of procollagen V with procollagen I, pC-collagen I, procollagen IV, and a Drosophila procollagen.

Journal of Biological Chemistry, 1982
Chick embryo procollagen V, procollagen I, and pC-collagen I were sprayed, rotary shadowed, and compared electronmicroscopically with mouse procollagen IV and Drosophila procollagen produced by cell cultures and prepared in the same way. All the molecules appeared as threads and had a prominent knob protrusion at one end.
H P, Bächinger, K J, Doege, J P, Petschek, L I, Fessler, J H, Fessler   +4 more
openaire   +2 more sources

Dynamic Mechanical Loading Modulates Extracellular Vesicle Production and Cargo in Meniscus Fibrochondrocytes

Advanced Materials Interfaces, EarlyView.
Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung, Zizhao Li, Sung‐Han Jo, Se‐Hwan Lee, Il Keun Kwon, Jina Ko, Su Chin Heo   +6 more
wiley   +1 more source

Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo

Journal of Lipid Research, 2008
In an effort to find topical agents that prevent or retard cutaneous aging, seven functional lipids were screened for their procollagen-upregulating and matrix metalloproteinase (MMP)-1-downregulating activities in human dermal fibroblasts by Western ...
Soyun Cho, Hyeon Ho Kim, Min Jung Lee, Serah Lee, Chang-Seo Park, Sang-June Nam, Jeong-Jun Han, Jin-Wook Kim, Jin Ho Chung   +8 more
doaj   +1 more source

Validation of COL11A1/procollagen 11A1 expression in TGF-β1-activated immortalised human mesenchymal cells and in stromal cells of human colon adenocarcinoma

BMC Cancer, 2014
BackgroundThe human COL11A1 gene has been shown to be up-regulated in stromal cells of colorectal tumours, but, so far, the immunodetection of procollagen 11A1, the primary protein product of COL11A1, has not been studied in detail in human colon ...
J. Galván, Jorge García-Martínez, Fernando Vázquez-Villa, Marcos García-Ocaña, C. García-Pravia, P. Menéndez-Rodríguez, Carmen González-del Rey, L. Barneo-Serra, J. R. de los Toyos   +8 more
semanticscholar   +1 more source