Results 11 to 20 of about 5,414 (155)

Delirium-Onset of Prodromal Dementia With Lewy Bodies—Putative Brainstem-Related Pathomechanism and Clinical Relevance [PDF]

Frontiers in Aging Neuroscience, 2022
Niels Hansen, Charles Timäus, Caroline Bouter, Claudia Lange, Katharina Packroß   +4 more
doaj   +2 more sources

Clinical characteristics of pathological confirmed prodromal dementia with Lewy bodies. [PDF]

J Neurol Sci, 2023
Misdiagnosis rate of Dementia with Lewy Bodies (DLB) remains high despite being second most common cause of neurodegenerative dementia. To date, understanding of clinical profile of pathologically confirmed prodromal DLB remains limited. The main objective of this study was to describe and compare it with pathologically confirmed Alzheimer's disease ...
Ting SKS, Saffari SE, Hameed S, Chiew HJ, Ng KP, Ng AS.   +5 more
europepmc   +3 more sources

Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression. [PDF]

Mov Disord, 2020
AbstractObjectiveThe objective of this study was to examine clinical characteristics, cognitive decline, and predictors for time to dementia in prodromal dementia with Lewy bodies with mild cognitive impairment (MCI‐LB) compared with prodromal Alzheimer's disease (MCI‐AD).MethodsWe included 73 MCI‐LB patients (12% female; 68 ± 6 years; Mini Mental ...
van de Beek M, van Steenoven I, van der Zande JJ, Barkhof F, Teunissen CE, van der Flier WM, Lemstra AW.   +6 more
europepmc   +7 more sources

Prodromal Dementia With Lewy Bodies: Evolution of Symptoms and Predictors of Dementia Onset. [PDF]

J Geriatr Psychiatry Neurol, 2022
Background: Research criteria for prodromal dementia with Lewy bodies (DLB) were published in 2020, but little is known regarding prodromal DLB in clinical settings. Methods: We identified non-demented participants without neurodegenerative disease from the National Alzheimer’s Coordinating Center Uniform Data Set who converted to DLB at a subsequent ...
Wyman-Chick KA, O'Keefe LR, Weintraub D, Armstrong MJ, Rosenbloom M, Martin PK, Barclay TR, Barrett MJ.   +7 more
europepmc   +3 more sources

Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration. [PDF]

Brain Commun, 2022
Abstract Mild cognitive impairment with the core clinical features of dementia with Lewy bodies is recognized as a prodromal stage of dementia with Lewy bodies. Although grey matter atrophy has been demonstrated in prodromal dementia with Lewy bodies, longitudinal rates of atrophy during progression to probable dementia with Lewy bodies ...
Kantarci K, Nedelska Z, Chen Q, Senjem ML, Schwarz CG, Gunter JL, Przybelski SA, Lesnick TG, Kremers WK, Fields JA, Graff-Radford J, Savica R, Jones D, Botha H, Knopman DS, Lowe V, Graff-Radford NR, Murray MM, Dickson DW, Reichard RR, Jack CR, Petersen RC, Ferman TJ, Boeve BF.   +23 more
europepmc   +3 more sources

Research criteria for the diagnosis of prodromal dementia with Lewy bodies. [PDF]

Neurology, 2020
The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-
McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O'Brien JT, Postuma RB, Aarsland D, Ballard C, Bonanni L, Donaghy P, Emre M, Galvin JE, Galasko D, Goldman JG, Gomperts SN, Honig LS, Ikeda M, Leverenz JB, Lewis SJG, Marder KS, Masellis M, Salmon DP, Taylor JP, Tsuang DW, Walker Z, Tiraboschi P, prodromal DLB Diagnostic Study Group.   +30 more
europepmc   +10 more sources

Locus coeruleus alterations in dementia with Lewy bodies: A systematic review [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION The locus coeruleus (LC) is a small nucleus located deep within the brainstem, serving as the brain's main source of noradrenergic neurons.
Anaëlle Bain, Charlotte Tomeo, Claire André, Antoine Garnier‐Crussard, Robin deFlores, Sophie Dautricourt   +5 more
doaj   +2 more sources

Cognitive profile in prodromal dementia with Lewy bodies. [PDF]

Alzheimers Res Ther, 2017
Cortical and subcortical cognitive impairments have been found in dementia with Lewy bodies (DLB). Roughly, they comprise visuoconstructive and executive dysfunction, whereas memory would remain relatively spared. However, the cognitive profile of patients with prodromal DLB remains poorly illustrated to date.We included 37 patients with prodromal DLB (
Kemp J, Philippi N, Phillipps C, Demuynck C, Albasser T, Martin-Hunyadi C, Schmidt-Mutter C, Cretin B, Blanc F.   +8 more
europepmc   +4 more sources

Characterising the prodromal phase of dementia with Lewy bodies [PDF]

Alzheimer's & Dementia, 2022
AbstractBackgroundThree subtypes of prodromal dementia with Lewy bodies (DLB) have recently been proposed. This study investigates the frequency of symptoms in the prodromal phase of DLB.MethodPatients diagnosed with DLB between the 1st of February 2017 and 1st of February 2021 were retrospectively identified and matched to a group of patients with ...
Clara Mellergaard, Gunhild Waldemar, Asmus Vogel, Kristian Steen Frederiksen   +3 more
openaire   +3 more sources

Immune Profiling in Early Cognitive Disorders (IMPRINT) study protocol: a longitudinal cohort study exploring biomarkers of inflammation in early dementia with Lewy bodies and Alzheimer’s disease, as part of the Dementias Platform UK [PDF]

BMJ Open
Introduction Growing evidence points towards the integral role of both central and peripheral inflammation across all neurodegenerative diseases, including dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD).
James B Rowe, Paresh Malhotra, Anna McKeever, Li Su, Peter Swann, Lina Aimola, Dan Blackburn, George Savulich, Leonidas Chouliaras, John T O’Brien, Paul M Matthews, Harry Crook, Haddy Fye, Stacey Kigar, Elena Herrero, Lordina Turner, Gabrielle D Grey   +16 more
doaj   +2 more sources