Results 21 to 30 of about 5,414 (155)

Distinguishing Prodromal Dementia With Lewy Bodies From Prodromal Alzheimer Disease: A Longitudinal Study. [PDF]

Neurol Clin Pract
It can be clinically challenging to differentiate dementia with Lewy bodies (DLB) and Alzheimer disease (AD). As potential therapies emerge with the goal of slowing or halting misfolded protein aggregation, it is imperative to be able to identify individuals before the disease becomes disabling.
Wyman-Chick KA, Ferman TJ, Weintraub D, Armstrong MJ, Boeve BF, Bayram E, Chrenka E, Barrett MJ.   +7 more
europepmc   +3 more sources

Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies. [PDF]

Psychol Med, 2019
AbstractBackgroundDopaminergic imaging has high diagnostic accuracy for dementia with Lewy bodies (DLB) at the dementia stage. We report the first investigation of dopaminergic imaging at the prodromal stage.MethodsWe recruited 75 patients over 60 with mild cognitive impairment (MCI), 33 with probable MCI with Lewy body disease (MCI-LB), 15 with ...
Thomas AJ, Donaghy P, Roberts G, Colloby SJ, Barnett NA, Petrides G, Lloyd J, Olsen K, Taylor JP, McKeith I, O'Brien JT.   +10 more
europepmc   +5 more sources

Assessing Nigrostriatal Dopaminergic Pathways via 123I-FP-CIT SPECT in Dementia With Lewy Bodies in a Psychiatric Patient Cohort

Frontiers in Aging Neuroscience, 2021
Background(123)-I-2-ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortro- pane single photon emission computed tomography (123I-FP-CIT SPECT) was validated to distinguish Alzheimer’s dementia from dementia with Lewy Bodies (DLB) by European medical
Niels Hansen, Claudia Lange, Charles Timäus, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Caroline Bouter   +6 more
doaj   +1 more source

New Insights into Potential Biomarkers in Patients with Mild Cognitive Impairment Occurring in the Prodromal Stage of Dementia with Lewy Bodies

Brain Sciences, 2023
Background: Prodromal dementia with Lewy bodies (DLB) can emerge with the onset of mild cognitive impairment (MCI). Standard biomarkers can help identify such patients to improve therapy and treatment strategies.
Niels Hansen, Caroline Bouter, Sebastian Johannes Müller, Christoph van Riesen, Eya Khadhraoui, Marielle Ernst, Christian Heiner Riedel, Jens Wiltfang, Claudia Lange   +8 more
doaj   +1 more source

Prodromal dementia with Lewy bodies [PDF]

Psychological Medicine, 2014
BackgroundThe clinical condition of dementia is now recognized as a diagnosis that can only be applied too late in the disease process to be useful for therapeutic approaches centring on disease modification. As a result, in recent years increasing attention has been given to mild cognitive impairment (MCI) and the diagnosis of prodromal dementia. This
P C, Donaghy, J T, O'Brien, A J, Thomas
openaire   +2 more sources

Evolution of Prodromal Multiple System Atrophy from REM Sleep Behavior Disorder: A Descriptive Study

Journal of Parkinson’s Disease, 2022
Background: Prodromal multiple system atrophy (MSA) has been characterized mainly by retrospective chart reviews. Direct observation and tracking of prodromal markers in MSA have been very limited Objective: To report the baseline characteristics and ...
Ronald B. Postuma, Amelie Pelletier, Jean-Francois Gagnon, Jaccques Montplaisir   +3 more
doaj   +1 more source

Clinico-imaging features of subjects at risk of Lewy body disease in NaT-PROBE baseline analysis

npj Parkinson's Disease, 2023
Individuals with prodromal symptoms of Lewy body disease (LBD), such as rapid eye movement sleep behavior disorder (RBD), often showed imaging defects similar to patients with Parkinson’s disease and dementia with Lewy bodies.
Makoto Hattori, Keita Hiraga, Yuki Satake, Takashi Tsuboi, Daigo Tamakoshi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Akihiro Hori, Motoshi Kawashima, Hideaki Shimizu, Hiroshi Matsuda, Katsuhiko Kato, Yukihiko Washimi, Masahisa Katsuno   +15 more
doaj   +1 more source

Occipital atrophy signature in prodromal Lewy bodies disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
INTRODUCTION Dementia with Lewy bodies (DLB) is typically characterized by parietal, temporal, and occipital atrophy, but less is known about the newly defined prodromal phases.
Alice Galli, Andrea Pilotto, Benedetta Chiarini, Marcello Giunta, Daniele Corbo, Clara Tirloni, Daniel Ferreira, Enrico Premi, Alessandro Lupini, Cinzia Zatti, Laura Bonanni, Pietro Tiraboschi, Roberto Gasparotti, Alessandro Padovani   +13 more
doaj   +1 more source

Lewy Body Dementias: A Coin with Two Sides?

Behavioral Sciences, 2021
Lewy body dementias (LBDs) consist of dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), which are clinically similar syndromes that share neuropathological findings with widespread cortical Lewy body deposition, often with a ...
Ángela Milán-Tomás, Marta Fernández-Matarrubia, María Cruz Rodríguez-Oroz   +2 more
doaj   +1 more source

Autonomic dysfunction in dementia with Lewy bodies: Focusing on cardiovascular and respiratory dysfunction

PCN Reports, 2023
Dementia with Lewy bodies (DLB) is the second most common cause of dementia after Alzheimer's disease. The disease is characterized by many Lewy bodies appearing in the patient's cerebrum. DLB frequently presents with a variety of autonomic symptoms from
Katsuyoshi Mizukami
doaj   +1 more source