Results 71 to 80 of about 5,414 (155)

Synuclein Disorder‐Related Genetic Determinants of Mild Behavioural Impairment in a Pre‐Clinical Community Cohort

International Journal of Geriatric Psychiatry, Volume 41, Issue 3, March 2026.
ABSTRACT Background The GBA variant confers increased risk of synuclein disorders but it is unclear what impact it has in pre‐clinical groups. This study aimed to identify early psychiatric and cognitive manifestations amongst pre‐clinical GBA carriers in a community cohort.
Millie Sander‐Long, Byron Creese, Anne Corbett, Ivana Rosenzweig, Jeffrey Cummings, Clive Ballard   +5 more
wiley   +1 more source

Phase II pilot randomized trial of zonisamide for disease modification in prodromal Lewy body disease

npj Parkinson's Disease
Zonisamide exhibits potential neuroprotective properties, but its efficacy during the prodromal stage of Lewy body disease (LBD) remains unclear. In this phase II randomized, double-blind pilot trial, 29 high-risk individuals aged 50–80 years with ≥2 ...
Keita Hiraga, Makoto Hattori, Daigo Tamakoshi, Yuki Satake, Taiki Fukushima, Yuki Saito, Takashi Uematsu, Takashi Tsuboi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Yoshino Ueki, Fumie Kinoshita, Hiroshi Matsuda, Akihiro Murata, Masayuki Yamamoto, Masakazu Wakai, Noriyuki Matsukawa, Yukihiko Washimi, Masahisa Katsuno   +20 more
doaj   +1 more source

Bipolar Disorder as a Long‐Term Risk Factor for Parkinson's Disease: A Nationwide Case–Control Study

Movement Disorders, Volume 41, Issue 3, Page 690-698, March 2026.
Abstract Background Previous studies suggest an association between bipolar disorder (BD) and an increased risk of Parkinson's disease (PD), but the long‐term temporal relationship remains unclear. Particularly, it is unclear whether the risk of PD is influenced by the duration since BD diagnosis.
Elina Jaakkola, Marjaana Koponen, Valtteri Kaasinen, Jarmo Hietala, Sirpa Hartikainen, Anna‐Maija Tolppanen   +5 more
wiley   +1 more source

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection, Volume 4, Issue 1, Page 14-29, March 2026.
Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
wiley   +1 more source

Associations of living alone and loneliness with neuropsychiatric symptoms in individuals with mild cognitive impairment: A retrospective cross‐sectional study

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim Living alone and loneliness are recognized risk factors for neuropsychiatric symptoms in older adults. However, the distinct of the objective condition of living alone and subjective loneliness on specific neuropsychiatric symptoms in individuals with mild cognitive impairment (MCI) remains unclear.
Kayo Takeda, Hideki Kanemoto, Takashi Suehiro, Yuto Satake, Daiki Taomoto, Shigeki Katakami, Kenji Yoshiyama, Manabu Ikeda   +7 more
wiley   +1 more source

Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease

npj Parkinson's Disease
Comorbid Alzheimer’s disease (AD) neuropathology is common in Lewy body disease (LBD); however, AD comorbidity in the prodromal phase of LBD remains unclear.
Keita Hiraga, Makoto Hattori, Yuki Satake, Daigo Tamakoshi, Taiki Fukushima, Takashi Uematsu, Takashi Tsuboi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Yukihiko Washimi, Akihiro Hori, Masayuki Yamamoto, Hideaki Shimizu, Masakazu Wakai, Harutsugu Tatebe, Takahiko Tokuda, Akinori Nakamura, Shumpei Niida, Masahisa Katsuno   +20 more
doaj   +1 more source

Oculo-Visual Dysfunction in Parkinson’s Disease

Journal of Parkinson’s Disease
This review describes the oculo-visual problems likely to be encountered in Parkinson’s disease (PD) with special reference to three questions: (1) are there visual symptoms characteristic of the prodromal phase of PD, (2) is PD dementia associated with ...
R.A. Armstrong
doaj   +1 more source

α-synuclein seed amplification assay sensitivity may be associated with cardiac MIBG abnormality among patients with Lewy body disease

npj Parkinson's Disease
Although α-synuclein seed amplification assays (α-syn SAA) are promising, its sensitivity may be affected by heterogeneity among patients with Lewy body disease (LBD). We evaluated whether α-syn SAA sensitivity is affected by patient heterogeneity, using
Masanori Kurihara, Katsuya Satoh, Ryosuke Shimasaki, Keiko Hatano, Kensuke Ohse, Kenichiro Taira, Ryoko Ihara, Mana Higashihara, Yasushi Nishina, Masashi Kameyama, Atsushi Iwata   +10 more
doaj   +1 more source

Use of Artificial Intelligence in Imaging Dementia

Cells
Alzheimer’s disease is the most common cause of dementia in the elderly population (aged 65 years and over), followed by vascular dementia, Lewy body dementia, and rare types of neurodegenerative diseases, including frontotemporal dementia.
Manal Aljuhani, Azhaar Ashraf, Paul Edison   +2 more
doaj   +1 more source

Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum

npj Parkinson's Disease
Cerebrovascular disease is common in patients on the Lewy body (LB) continuum (dementia with Lewy bodies (DLB) and prodromal-DLB). White matter signal abnormality (WMSA) volume is higher in patients with LB than controls, both globally and in cholinergic
Anna Rennie, Milan Nemy, Cene Jerele, Iñigo Rodríguez-Baz, Victor Montal, Alexandre Bejanin, Milica G Kramberger, Dag Aarsland, Juan Fortea, Alberto Lleó, Eric Westman, Daniel Alcolea, Daniel Ferreira   +12 more
doaj   +1 more source