Results 71 to 80 of about 73,102 (302)

Redox-responsive core cross-linked prodrug micelles prepared by click chemistry for pH-triggered doxorubicin delivery

eXPRESS Polymer Letters, 2017
A pH-triggered drug delivery system of degradable core cross-linked (CCL) prodrug micelles was prepared by click chemistry. Doxorubicin conjugated block copolymers of azido functional poly(ethylene oxide)-b-poly(glycidyl methacrylate) were synthesized by
X. T. Cao, C. M. Q. Le, H. H. P. Thi, G-D. Kim, Y-S. Gal, K. T. Lim   +5 more
doaj   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Mitochondrial targeted prodrug nanoparticles for chemo-photodynamic combinational tumour therapy

Smart Materials in Medicine
Prodrug nanoparticles have been explored as an effective means for drug delivery because of controlled drug release in a stimulus-responsive manner. Organellar-targeted drug delivery could enhance the efficacy of cancer therapy. Herein, pH and light dual
Rong Xu, Encan Zhu, Xiaoyun Lan, Qihang Yang, Chuangnian Zhang   +4 more
doaj   +1 more source

Pectin–metronidazole prodrug bearing microspheres for colon targeting

Journal of Saudi Chemical Society, 2015
The present study explored the potential of pectin–metronidazole (PT–ME) prodrug bearing microspheres for colon delivery. PT–ME prodrug was synthesized with different degree of substitution. The success of the synthesis was confirmed by spectroscopy.
Ankur Vaidya, Shweta Jain, Ram K. Agrawal, Sanjay K. Jain   +3 more
doaj   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Predicting inadequate postoperative pain management in depressed patients: A machine learning approach.

PLoS ONE, 2019
Widely-prescribed prodrug opioids (e.g., hydrocodone) require conversion by liver enzyme CYP-2D6 to exert their analgesic effects. The most commonly prescribed antidepressant, selective serotonin reuptake inhibitors (SSRIs), inhibits CYP-2D6 activity and
Arjun Parthipan, Imon Banerjee, Keith Humphreys, Steven M Asch, Catherine Curtin, Ian Carroll, Tina Hernandez-Boussard   +6 more
doaj   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Ameliorated in vitro anticancer efficacy of methotrexate d-α-Tocopheryl polyethylene glycol 1000 succinate ester against breast cancer cells

Future Journal of Pharmaceutical Sciences, 2019
Background Methotrexate (MTX), a folate anti-metabolite, has been used widely in the treatment of plenty of malignancies. However, the clinical use is limited because of its poor water solubility (BCS class II drug), nonspecific distribution, drug ...
Arehalli S. Manjappa, Popat S. Kumbhar, Rohini Kasabe, Sonali K. Diwate, John I. Disouza   +4 more
doaj   +1 more source

Bioreversible Derivatization of Drug Molecules with a Pyridine Ring for Improved Water Solubility: Model Studies

A prodrug is a modified drug molecule having no significant biological activity but converts to the parent drug in the biological system. Conventionally, the prodrug is designed and synthesized by modifying a functional group that serves as a ‘synthetic ...
Bansal, Shubham
core   +1 more source

Spatiotemporally Precise Rheumatoid Arthritis Therapy via a Triple‐Locked Cascaded Nanoplatform With Dual‐Channel Self‐Reporting [PDF]

Advanced science
An orthogonally programmable nanotheranostic (MB@YW NPs) enables precision therapy for rheumatoid arthritis. A triple‐locked (pH, HOCl/ONOO−, light) independently drives the release of methotrexate and sulfasalazine. Trackable by dual‐channel fluorescence, this coordinated drug delivery remodels the inflammatory microenvironment to markedly suppress ...
Liu J, Zhu W, Xu S, Liu S, Tang W, Ma X, Yang T, Yang H, Wang H, Cao L, Tan L, Wang Q.   +11 more
europepmc   +2 more sources