Results 91 to 100 of about 65,300 (300)
N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool
Molecular Therapy: Nucleic Acids, 2020 MicroRNAs (miRNAs or miRs) play crucial roles in biological and pathological processes. Some miRNAs also appear as promising biomarkers and therapeutic tools. However, the epitranscriptomic regulation of miRNAs is not yet fully elucidated in all of their
Joséphine Briand +7 more
doaj +1 more source
, 2022 Min Du,1 Jianbo Yin2 1Department of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, 214000, People’s Republic of China; 2Department of Pharmacy, Wuxi Dashan Medical Beauty Clinic, Wuxi, Jiangsu Province, 214001, People’s ...
Du M, Yin J
core
A Dual-Mechanism Targeted Bioorthogonal Prodrug Therapy
, 2023 Bioorthogonal prodrug therapies offer an intriguing two-component system that features enhanced circulating stability and controlled activation on demand.
Qingxin Yao (8676756) +8 more
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Advanced NanoBiomed Research, EarlyView.Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq +5 more
wiley +1 more source
A prodrug is a modified drug molecule having no significant biological activity but converts to the parent drug in the biological system. Conventionally, the prodrug is designed and synthesized by modifying a functional group that serves as a ‘synthetic ...
Bansal, Shubham
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, 2021 Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle–based drug delivery systems of chemotherapy.
Weijia Zeng (9724088) +9 more
core +1 more source
Angewandte Chemie, EarlyView.Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley +1 more source
pH Sensitive Anticancer Prodrug: Amide of Kemp's Acid
, 2009 Solid tumours are characterised by lower extracellular pH (as low as 5.8 pH) compared to normal healthy cellular pH (actively regulated at pH 7.3). This difference may be exploited with an acid-sensitive anti-tumour prodrug which releases a cytotoxin ...
Brooks, Robert Turongo
core
, 2021 Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle–based drug delivery systems of chemotherapy.
Weijia Zeng (9724088) +9 more
core +1 more source
Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis
Molecules, 2018 Antifolates targeting folate biosynthesis within the shikimate-chorismate-folate metabolic pathway are ideal and selective antimicrobials, since higher eukaryotes lack this pathway and rely on an exogenous source of folate.
Carmen Sadaka +5 more
doaj +1 more source