Results 91 to 100 of about 73,102 (302)

Engineering Rapid Payload Release Rate in 1,6‐Elimination Processes of Self‐Immolative Linkers

Angewandte Chemie, EarlyView.
The payload release rate of self‐immolative linkers was greatly improved through stabilization of an intermediate carbocation, thereby achieving an up to 10 000‐fold improvement in rate constant. Furthermore, lipophilicity was identified as another factor that affects the release rate. This new strategy is applicable to different payloads and different
Albert Marten Schulte, Gülbahar Bozan, Francesca Amoroso, Bart Cornelissen, Wiktor Szymanski   +4 more
wiley   +2 more sources

Supplementary Data from Image-Guided Enzyme/Prodrug Cancer Therapy

, 2008
Supplementary Data from Image-Guided Enzyme/Prodrug Cancer ...
Paul Winnard (14980056), Zaver M. Bhujwalla (309849), Marie-France Penet (309845), Cong Li (115171), Dmitri Artemov (513792)   +4 more
core   +1 more source

Activatable MR Prodrug for Targeted Delivery and Treatment of Cancer [PDF]

, 2021
In this study, a new multimodal theranostic tool is reported utilizing nanoceria delivery system conjugated with the ICAM1 antibody and a magnetic resonance (MR) probe as a prodrug with both MR and cytotoxic properties.
Banerjee, Tuhina, Patel, Truptiben, Shaw, Zachary, Santra, Santimukul, Patel, Arth   +4 more
core  

Prodrug Synthesis using Paclitaxel and Hybrid Peptides [PDF]

, 2017
Prodrug Synthesis using Paclitaxel and Hybrid Peptides Anthony Sablan Biochemistry 2017 ...
Sablan, Anthony
core  

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Prodrug-based nanomedicines for rheumatoid arthritis

Discover Nano
Most antirheumatic drugs with high toxicity exhibit a narrow therapeutic window due to their nonspecific distribution in the body, leading to undesirable side effects and reduced patient compliance.
Pei Li, Cong Wang, Hongjie Huo, Chunyun Xu, Huijun Sun, Xinyu Wang, Li Wang, Lei Li   +7 more
doaj   +1 more source

Synthesis, Characterization and Biological Evaluation of Succinate Prodrugs of Curcuminoids for Colon Cancer Treatment

Molecules, 2011
A novel series of succinyl derivatives of three curcuminoids were synthesized as potential prodrugs. Symmetrical (curcumin and bisdesmethoxycurcumin) and unsymmetrical (desmethoxycurcumin) curcuminoids were prepared through aldol condensation of 2,4 ...
Pornchai Rojsitthisak, Ubonthip Nimmannit, Sumrit Wacharasindhu, Wisut Wichitnithad   +3 more
doaj   +1 more source

Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers

, 2017
Shuqin Ni, Lei Qiu, Guodong Zhang, Haiyan Zhou, Yong Han Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, Shandong, People’s Republic of China
Zhang G, Han Y, Ni S, Zhou H, Qiu L
core  

DataSheet2_A Co-delivery System Based on a Dimeric Prodrug and Star-Shaped Polymeric Prodrug Micelles for Drug Delivery.PDF

, 2021
Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle–based drug delivery systems of chemotherapy.
Weijia Zeng (9724088), Xiaoqing Yang (584135), Lulu Zhang (104611), Tingting Chen (111216), Man Zhou (196972), Xiaoyan He (417003), Xiuguang Yi (9539573), Yongxiu Li (1633876), Xiaoqing Yi (5434118), Yan Luo (255674)   +9 more
core   +1 more source

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source