Results 111 to 120 of about 71,065 (294)
Prodrug design : perspectives, approaches and applications in medicinal chemistry /
Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the ...
Bari, Sanjay B.,author. +1 more
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Angewandte Chemie, EarlyView.Lichtaktivierbare Iridium(III)‐Prodrugs zeigen, wie die Koordination von Chalkogenen die photoinduzierte therapeutische Aktivität steuert. Bei Bestrahlung mit sichtbarem Licht laufen an den schwefel‐ bzw. selenhaltigen Liganden unterschiedliche, sauerstoffabhängige Photoreaktionen ab.
Victoria V. L. Müller +5 more
wiley +1 more source
International Journal of Nanomedicine, 2011 Bart J Crielaard1, Steffen van der Wal1, Twan Lammers2, Huong Thu Le1, Wim E Hennink1, Raymond M Schiffelers1, Gert Storm1, Marcel HAM Fens11Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The ...
Crielaard BJ +7 more
doaj
Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy
International Journal of Nanomedicine, 2020 Weiwei Wang,1 Junting Fan,2 Guang Zhu,1 Jing Wang,1 Yumei Qian,1 Hongxia Li,1 Jianming Ju,3 Lingling Shan1 1Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Key Laboratory of Spin Electron and Nanomaterials of Anhui ...
Wang W +7 more
doaj
Nature CommunicationsThe prodrug design strategy offers a potent solution for improving therapeutic index and expanding drug targets. However, current prodrug activation designs are mainly responsive to endogenous stimuli, resulting in unintended drug release and systemic ...
Xinyu He +7 more
doaj +1 more source
Prodrugs eller prodruger? [PDF]
Tidsskrift for Den norske legeforening, 2016 openaire +1 more source
, 2014 Johannah Sharman, Michael Pennick Shire, Basingstoke, UK Abstract: Lisdexamfetamine dimesylate (LDX) is approved as a once-daily treatment for attention-deficit/hyperactivity disorder in children, adolescents, and adults in some countries.
Sharman J, Pennick M
core
Ribonuclease-Activated Cancer Prodrug
, 2016 Cancer chemotherapeutic agents often have a narrow therapeutic index that challenges the maintenance of a safe and effective dose. Consistent plasma concentrations of a drug can be obtained by using a timed-release prodrug strategy.
Gregory A. Ellis (1283733) +3 more
core +1 more source