Results 101 to 110 of about 65,300 (300)

Prodrug-based nanomedicines for rheumatoid arthritis

Discover Nano
Most antirheumatic drugs with high toxicity exhibit a narrow therapeutic window due to their nonspecific distribution in the body, leading to undesirable side effects and reduced patient compliance.
Pei Li, Cong Wang, Hongjie Huo, Chunyun Xu, Huijun Sun, Xinyu Wang, Li Wang, Lei Li   +7 more
doaj   +1 more source

Advances in prodrug design

, 2005
The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy)
Carvalho Güido, Rafael Victorio, Castro, Lúcia Fioravanti, Ferreira, Elizabeth Igne, Távora de Albuquerque Silva, Antonio, Chin, Chung Man, Chin, Chung Man [UNESP], Castro, Lúcia Fioravanti [UNESP], Távora de Albuquerque Silva, Antonio [UNESP], Carvalho Güido, Rafael Victorio [UNESP]   +8 more
core   +1 more source

NQO1-Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell-Targeted Migrastatic

Migrastatic drugs targeting cell motility and suppressing invasiveness of solid tumors, have the potential to bring about a paradigm shift in the treatment of solid cancer.
Kagho, Mervic D.,, Rottner, Klemens,, Venkatakrishnan, Vignesh,, Stadler, Marc, Schmidt, Katharina,, Rottner, Klemens, Dongock Kagho, Mervic D.,, Lambert, Christopher, Stradal, Theresia E. B., Bylund, Johan,, Klahn, Philipp,, Schmidt, Katharina, Jia, Lili, Mehr, Luisa, Mehr, Luisa,, Stradal, Theresia E. B.,, Lambert, Christopher,, Venkatakrishnan, Vignesh, Jia, Lili,, Stadler, Marc,   +19 more
core   +1 more source

A hypoxia-activated antibacterial prodrug

, 2020
A prodrug based on a known antibacterial compound is reported to target Staphylococcus aureus and Escherichia coli under reductive conditions. The prodrug was prepared by masking the N-terminus and side chain amines of a component lysine residue as 4 ...
Polyak, S.W., Horsley, J.R., Yeoh, Y.Q., Abell, A.D.   +3 more
core   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy

Asian Journal of Pharmaceutical Sciences
Small-molecule prodrug nanoassembly technology with a unique advantage in off-target toxicity reduction has been widely used for antitumor drug delivery.
Ziqi Lin, Yuequan Wang, Wenwen Li, Fei Sun, Qingzhi Lv, Shenwu Zhang, Xiaohong Liu, Feng Qin, Cong Luo   +8 more
doaj   +1 more source

Synthesis and Biological Evaluation of Liguzinediol Mono- and Dual Ester Prodrugs as Promising Inotropic Agents

Molecules, 2014
The potent positive inotropic effect, together with the relatively low safety risk of liguzinediol (LZDO), relative to currently available inotropic drugs, has prompted us to intensively research and develop LZDO as a potent positive inotropic agent.
Jing Zhang, Wei Li, Hong-Mei Wen, Hao-Hao Zhu, Tian-Lin Wang, Dong Cheng, Kun-Di Yang, Yu-Qing Chen   +7 more
doaj   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers

, 2017
Shuqin Ni, Lei Qiu, Guodong Zhang, Haiyan Zhou, Yong Han Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, Shandong, People’s Republic of China
Zhang G, Han Y, Ni S, Zhou H, Qiu L
core  

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source