Results 101 to 110 of about 73,102 (302)

Glutaredoxine reduzieren schnell Glutathionhydroper‐ und Glutathionpolysulfide

Angewandte Chemie, EarlyView.
Glutaredoxine (Grx) reduzieren Glutathionpolysulfide (GSSnSG) schnell zu Glutathionhydroper/polysulfiden (GSSnH) oder GSSnH zu Wasserstoff(poly)sulfiden (H2Sn). Die Reduktion glutathionylierter Grx durch reduziertes Glutathion (GSH) liefert Glutathiondisulfid (GSSG).
Philipp Reinert, Seiryo Ogata, Laura Leiskau, Sernur Sena Yildiz, Takaaki Akaike, Uladzimir Barayeu, Marcel Deponte   +6 more
wiley   +1 more source

Supplementary Movie S1 from Image-Guided Enzyme/Prodrug Cancer Therapy

, 2008
Supplementary Movie S1 from Image-Guided Enzyme/Prodrug Cancer ...
Paul Winnard (14980056), Zaver M. Bhujwalla (309849), Marie-France Penet (309845), Cong Li (115171), Dmitri Artemov (513792)   +4 more
core   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy

Asian Journal of Pharmaceutical Sciences
Small-molecule prodrug nanoassembly technology with a unique advantage in off-target toxicity reduction has been widely used for antitumor drug delivery.
Ziqi Lin, Yuequan Wang, Wenwen Li, Fei Sun, Qingzhi Lv, Shenwu Zhang, Xiaohong Liu, Feng Qin, Cong Luo   +8 more
doaj   +1 more source

A PAMPA Assay as Fast Predictive Model of Passive Human Skin Permeability of New Synthesized Corticosteroid C-21 Esters

Molecules, 2012
The permeation properties of twenty newly synthesized α-alkoxyalkanoyl and α-aryloxyalkanoyl C-21 esters of standard corticosteroids: Fluocinolone acetonide, dexamethasone, triamcinolone acetonide and hydrocortisone were established using a PAMPA assay ...
Katarina D. Karljikovic-Rajic, Sote M. Vladimirov, Jadranka V. Odovic, Olivera A. Cudina, Bojan D. Markovic   +4 more
doaj   +1 more source

Use of a direct, positive selection strategy to generate improved prodrug-activating enzymes for cancer gene therapy [PDF]

, 2011
E. coli NfsB nitroreductase (NTR) is currently being studied in combination with the prodrug CB1954, as a gene directed enzyme prodrug therapy. NTR reduces CB1954 at either the 2- or 4-nitro groups to produce highly cytotoxic hydroxylamine derivatives ...
Baker, Shelley Louise
core   +3 more sources

Structures of the prodrug (DB868) and active compound (DB829).

, 2013
Structures of the prodrug (DB868) and active compound (DB829).
Arlene S. Bridges (301008), John K. Thuita (148377), Yao Chen (149006), Shelley Ching (148404), Grace A. Murilla (148401), Michael Zhuo Wang (418631), Mary F. Paine (148396), Mohamed A. Ismail (418629), James Edwin Hall (418630), James N. Mutuku (418628), Qiang Liu (166143), David W. Boykin (148406), Richard R. Tidwell (148409), Raymond E. Mdachi (148398), Reto Brun (41511), Kristina K. Wolf (418627)   +15 more
core   +1 more source

Click‐Spaltung quartärer Anilinium‐Tetrazine ermöglicht Kaskadenaufbau multifunktioneller biomolekularer Gerüste

Angewandte Chemie, EarlyView.
Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

1086 Modulating the tumor microenvironment via hypoxia activated prodrug CPD100Li induced cell death synergistically enhances anti-CTLA-4 immunotherapy

Journal for ImmunoTherapy of Cancer, 2023
August Sick
doaj   +1 more source

Lisdexamfetamine prodrug activation by peptidase-mediated hydrolysis in the cytosol of red blood cells

, 2014
Johannah Sharman, Michael Pennick Shire, Basingstoke, UK Abstract: Lisdexamfetamine dimesylate (LDX) is approved as a once-daily treatment for attention-deficit/hyperactivity disorder in children, adolescents, and adults in some countries.
Sharman J, Pennick M
core