Results 101 to 110 of about 71,065 (294)

Prodrug-based nanomedicines for rheumatoid arthritis

Discover Nano
Most antirheumatic drugs with high toxicity exhibit a narrow therapeutic window due to their nonspecific distribution in the body, leading to undesirable side effects and reduced patient compliance.
Pei Li, Cong Wang, Hongjie Huo, Chunyun Xu, Huijun Sun, Xinyu Wang, Li Wang, Lei Li   +7 more
doaj   +1 more source

NQO1-Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell-Targeted Migrastatic

Migrastatic drugs targeting cell motility and suppressing invasiveness of solid tumors, have the potential to bring about a paradigm shift in the treatment of solid cancer.
Kagho, Mervic D.,, Rottner, Klemens,, Venkatakrishnan, Vignesh,, Stadler, Marc, Schmidt, Katharina,, Rottner, Klemens, Dongock Kagho, Mervic D.,, Lambert, Christopher, Stradal, Theresia E. B., Bylund, Johan,, Klahn, Philipp,, Schmidt, Katharina, Jia, Lili, Mehr, Luisa, Mehr, Luisa,, Stradal, Theresia E. B.,, Lambert, Christopher,, Venkatakrishnan, Vignesh, Jia, Lili,, Stadler, Marc,   +19 more
core   +1 more source

Poly (ethylene glycol) prodrug for anthracyclines via N-Mannich base linker: Design, synthesis and biological evaluation

, 2009
Poly(ethylene glycol)s (PEGs) are potential drug carriers for improving the therapeutic index of anticancer agents. In this work, a novel methodology for constructing PEG prodrug of anthracycline anticancer drugs was developed based on N-Mannich base of ...
Zhao, Yong-Jiang, Yong-Jiang Zhao, Wei, Wei, Ma, GH, Wei Wei, Su, Zhi-Guo, Guang-Hui Ma, Zhi-Guo Su, Ma, Guang-Hui   +8 more
core   +1 more source

The protide prodrug technology: Where next? [PDF]

, 2019
The ProTide prodrug technology has proved very useful in the discovery of nucleotide therapeutics and has successfully led to two FDA-approved drugs. However, with the extensive application of this prodrug approach to nucleotides for nearly three decades,
Mehellou, Youcef, Alanazi, Ashwag S., James, Edward   +2 more
core   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Advances in prodrug design

, 2005
The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy)
Carvalho Güido, Rafael Victorio, Castro, Lúcia Fioravanti, Ferreira, Elizabeth Igne, Távora de Albuquerque Silva, Antonio, Chin, Chung Man, Chin, Chung Man [UNESP], Castro, Lúcia Fioravanti [UNESP], Távora de Albuquerque Silva, Antonio [UNESP], Carvalho Güido, Rafael Victorio [UNESP]   +8 more
core   +1 more source

A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy

Asian Journal of Pharmaceutical Sciences
Small-molecule prodrug nanoassembly technology with a unique advantage in off-target toxicity reduction has been widely used for antitumor drug delivery.
Ziqi Lin, Yuequan Wang, Wenwen Li, Fei Sun, Qingzhi Lv, Shenwu Zhang, Xiaohong Liu, Feng Qin, Cong Luo   +8 more
doaj   +1 more source

Synthesis and Biological Evaluation of Liguzinediol Mono- and Dual Ester Prodrugs as Promising Inotropic Agents

Molecules, 2014
The potent positive inotropic effect, together with the relatively low safety risk of liguzinediol (LZDO), relative to currently available inotropic drugs, has prompted us to intensively research and develop LZDO as a potent positive inotropic agent.
Jing Zhang, Wei Li, Hong-Mei Wen, Hao-Hao Zhu, Tian-Lin Wang, Dong Cheng, Kun-Di Yang, Yu-Qing Chen   +7 more
doaj   +1 more source

A hypoxia-activated antibacterial prodrug

, 2020
A prodrug based on a known antibacterial compound is reported to target Staphylococcus aureus and Escherichia coli under reductive conditions. The prodrug was prepared by masking the N-terminus and side chain amines of a component lysine residue as 4 ...
Polyak, S.W., Horsley, J.R., Yeoh, Y.Q., Abell, A.D.   +3 more
core   +1 more source

Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers

, 2017
Shuqin Ni, Lei Qiu, Guodong Zhang, Haiyan Zhou, Yong Han Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, Shandong, People’s Republic of China
Zhang G, Han Y, Ni S, Zhou H, Qiu L
core