Results 191 to 200 of about 73,540 (330)

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang, Hong‐Cheng Wei, Lin Jiang, Yi‐Sen Shao   +3 more
wiley   +1 more source

Redox Heterocyclic Platforms Engineered for Brain Drug Delivery and Beyond. [PDF]

Chem Rec
Papamicaël C, Gembus V, Gourand F, Levacher V.   +3 more
europepmc   +1 more source

Synthesis of 4-Aminoindole-Containing Cephalosporin Prodrugs and Their Biological Activity against <i>Mycobacterium tuberculosis</i>. [PDF]

ACS Infect Dis
Oh S, Boshoff HIM, Roma JSO, Boving A, Weiner DM, Walker A, Via LE, Barry CE.   +7 more
europepmc   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Coumarin-Based Prodrugs: Therapeutic Promise or Still Confined to Preclinical Exploration? [PDF]

Pharmaceutics
Chavez Alvarez AC, Moreau E.
europepmc   +1 more source

Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid). [PDF]

ACS Med Chem Lett
Sells CA, Kostyo JH, Gaykar RN, Kara MI, Lallande AT, Kane RR.   +5 more
europepmc   +1 more source

Continuous Subcutaneous Foslevodopa/Foscarbidopa in Advanced Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Continuous subcutaneous foslevodopa/foscarbidopa (LDp/CDp) provides 24‐h delivery of levodopa‐carbidopa prodrugs for advanced Parkinson's disease. Real‐world 1‐year European data remain limited. Objectives To characterize 1‐year changes in motor, non‐motor, autonomic, quality‐of‐life and sleep outcomes, and in concomitant therapy ...
Mario Hero, Nadja Grozdanić, Romana Brnić Andrić, Eliša Papić, Olivio Perković, Vladimira Vuletić   +5 more
wiley   +1 more source

4-Anilinoquinazoline carbamate derivatization as a platform for prodrug design and localized drug delivery. [PDF]

Bioorg Chem
Carpio MB, Walker CD, Fikes A, Laitinen T, Valdes-Pena MA, Gani O, Mallory M, Asquith CRM, Brudno Y, Pierce JG.   +9 more
europepmc   +1 more source

KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis

Med Research, EarlyView.
The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao, Guohui Yu, Shikui Wu, Zhiyang Zhang, Keke Wang, Yingxin Xiong, Chao Sun, Haobo Cui, Yuxing Wang, Ziheng Wang, Huiru Zhang, Huiqin Xue, Shibing Guo   +12 more
wiley   +1 more source

Breaking the Limitations of 'Milk': Research Progress on New Derivatives of Propofol. [PDF]

Molecules
Huang L, Xia Y, Shi J, Chen Y, Hao C.
europepmc   +1 more source