Results 211 to 220 of about 73,540 (330)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Plasma 3‐O‐Methyldopa Concentration Monitoring for Treatment Optimization in Foslevodopa/Foscarbidopa Infusion: Implications for Corrected Levodopa Availability: A Case Report

Movement Disorders Clinical Practice, EarlyView.
Shohei Okusa, Kotaro Okada, Yoshihiro Nihei, Risano Sakai, Takeshi Akiyoshi, Tomonori Nukariya, Jin Nakahara, Hisakazu Ohtani, Morinobu Seki   +8 more
wiley   +1 more source

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine. [PDF]

Drug Test Anal
Wellenberg SK, Wagmann L, Kroesen MD, Schippers P, Grill M, Herrmann J, Meyer MR.   +6 more
europepmc   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Tumor-Selective and Chemical Activation Strategies for Nitrogen Mustard Prodrugs. [PDF]

Chemistry
Ponnamperumage TNF, Mahendran M, Awoyera WO, Miller CJ, Ali T, Hill DE, Raschka NH, Peng X.   +7 more
europepmc   +1 more source

Remote‐Controlled Release of Nitric Oxide by Plasmonic Waveguide Coated With Metal–Organic Frameworks

Small, EarlyView.
Remote‐controlled intracellular delivery is achieved using a plasmonic waveguide coated with a photoresponsive NO‐releasing MOF. Surface plasmon polariton propagation remotely induces photocleavage and localized nitric oxide release in a target single live cell without direct light exposure, while biological relevance is demonstrated through transient ...
Tomoko Inose, Javier Lopez‐Cabrelles, Javier Troyano, Shun Tokuda, Elí Sánchez‐González, Nobuaki Takahashi, Yasuo Mori, Kenji Hirai, Hiroshi Uji‐i, Shuhei Furukawa   +9 more
wiley   +1 more source

Rational Design, Synthesis, and Systematic Evaluation of Redox-Responsive SN-38 Prodrugs for Selective Activation in Hypoxic Tumor Microenvironments. [PDF]

Pharmaceuticals (Basel)
Dong T, Xu J, Wang X, Sun Z, Wang S, Chen F, Zhu H, Zhang X, Xu S, Zheng C, Mao D, Ren T, Ni Q, Xu C, Shen X, Li N, Zhang D, Ji L, Guo H, Wang X.   +19 more
europepmc   +1 more source

Do We Need to Monitor B‐Vitamins and Homocysteine During Initiation of Foslevodopa/Foscarbidopa Therapy?

Movement Disorders, EarlyView.
Aida Shaghaghi‐Zadeh, Matthias Höllerhage, Florian Wegner, Lan Ye, Ishana Schneidereit, Tobias Hegelmaier, Rebecca Jacob, Christoph Schrader, Martin Klietz   +8 more
wiley   +1 more source

Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating

Small, EarlyView.
Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim, Lingqing Zong, Wei Deng, Maria Kavallaris, Zi Gu   +4 more
wiley   +1 more source