Results 201 to 210 of about 20,922 (255)

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Syntheses, Biological and Preclinical Evaluations, and Nanoparticle Formulations of the ROS-Activatable Prodrugs of Doxazolidine for Drug-Resistant Cancer Therapy. [PDF]

Mol Pharm
Tamura R, Grimm J.
europepmc   +1 more source

Negatively Charged Pronucleotides as Inhibitors of Glioma Cell Proliferation. [PDF]

ACS Med Chem Lett
Romanowska J, Wawrzyniak D, Szymanska-Michalak A, Framski G, Pawlowicz-Perczak A, Sobkowski M, Stawinski J, Rolle K, Kraszewski A.   +8 more
europepmc   +1 more source

Decoding the Hexosamine Biosynthesis Pathway: Implications for Novel Therapeutic Strategies in Sarcoma. [PDF]

J Cell Physiol
Rahimizadeh P, Miallot R, De Bellis C, Jolivet P, Przybyl J.   +4 more
europepmc   +1 more source

Nucleophile-triggered prodrug release from polymer hydrogels.

RSC Appl Polym
Klemm B, Tavasso M, Piergentili I, Satijn M, Brevé TG, Boukany PE, Eelkema R.   +6 more
europepmc   +1 more source

Prodrugs 2-(Phosphonomethyl)pentanedioic Acid (2-PMPA) as Orally Available Glutamate Carboxypeptidase II Inhibitors. [PDF]

ACS Med Chem Lett
Hin N, Lee CB, Gori S, Slusher BS, Rais R, Tsukamoto T.   +5 more
europepmc   +1 more source

Advances in Pharmacological Treatments for Cystinosis: Cysteamine and Its Alternatives. [PDF]

ACS Pharmacol Transl Sci
Carneiro A, Jones DH.
europepmc   +1 more source

Stereoselective synthesis of 1'-α-cyano carbocyclic pyrimidine nucleoside analogs <i>via</i> a chelation-controlled 1'-α-hydroxymethylation strategy.

Org Biomol Chem
Biteau NG, Kasthuri M, Patel D, De R, Schinazi RF, Amblard F.   +5 more
europepmc   +1 more source

Prodrugs for Amines [PDF]

Molecules, 2008
The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs.
Ana Luisa Simplicio, John F Gilmer
exaly   +4 more sources

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Prodrugs in medicinal chemistry and enzyme prodrug therapies

Advanced Drug Delivery Reviews, 2017
Prodrugs are cunning derivatives of therapeutic agents designed to improve the pharmacokinetics profile of the drug. Within a prodrug, pharmacological activity of the drug is masked and is recovered within the human body upon bioconversion of the prodrug, a process that is typically mediated by enzymes.
Raoul Walther, Jarkko Rautio, Alexander N Zelikin   +2 more
exaly   +3 more sources