Results 201 to 210 of about 33,100 (295)

Reductant-Responsive Squalene Dual-Prodrug Nanoparticles Co-Delivering Doxorubicin and Exatecan for Synergistic Breast Tumor Therapy. [PDF]

Pharmaceutics
Wang L, Yang N, Sa Y, Li Z, Qiao Y, Yang Y, Chen L, Liu X, Li L.   +8 more
europepmc   +1 more source

Multifunctional Nanoreactor Based on Catalyst Surface Engineering Combines pH‐Adaptive Catalysis With Tumor Microenvironment Modulation for Synergistic Chemodynamic‐Chemotherapy

Small, EarlyView.
A folate‐targeted Fe2O3@MoS2‐Pt/FA nanoreactor creates a localized acidic catalytic interface while simultaneously elevating intracellular H2O2 and consuming GSH. This dual regulation of reaction conditions and substrate availability markedly enhances Fenton‐driven chemodynamic therapy and synergistic chemotherapy for efficient tumor eradication ...
Yuchen Liu, Shan Lin, Pengyuan Song, Xianan Li, Jingwen Wang, Yang Zhang, Mingli Cai, Kang Fu, Ziyue Xu, Qianqian Zhao, Long Zhang, Jie Shen, Shibo Wang, Xiangdong Kong, Pu Chen   +14 more
wiley   +1 more source

Coumarin-Based Prodrugs: Therapeutic Promise or Still Confined to Preclinical Exploration? [PDF]

Pharmaceutics
Chavez Alvarez AC, Moreau E.
europepmc   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Membrane-Permeable Nucleoside T-1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides. [PDF]

Chemistry
Meier C, Li D, Persoons L, Andrei G, Snoeck R, Schols D, Naesens L, Jia X.   +7 more
europepmc   +1 more source

A single‐molecule prodrug synergistically suppresses MYC‐amplified osteosarcoma through sequential nitric oxide release and photodynamic therapy

Smart Molecules, EarlyView.
A cascade‐responsive small‐molecule prodrug (DHU‐NO3) sequentially releases methylene blue (triggered by reactive oxygen species) and nitric oxide (controlled by 405 nm light), enabling precise spatiotemporal coordination of photodynamic therapy and NO gas therapy to effectively inhibit MYC‐amplified osteosarcoma growth.
Shuxin Peng, Jiangpeng Wu, Shasha Wang, Ying Gao, Xuran Guo, Mengpan Li, Youjin Wu, Yun Wang, Zhengdong Cai, Yingqi Hua, Peng Wei, Yinghua Gao, Tao Yi   +12 more
wiley   +1 more source

Redox Heterocyclic Platforms Engineered for Brain Drug Delivery and Beyond. [PDF]

Chem Rec
Papamicaël C, Gembus V, Gourand F, Levacher V.   +3 more
europepmc   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

Conquering the stronghold: Membrane‐targeting anti‐infective drug discovery

Smart Molecules, EarlyView.
This perspective elucidates how XM‐01 and BLA combat infections through modulating pathogen membranes, disrupting biological processes, and potentiating therapeutics, offering cutting‐edge insights into anti‐infective drug mechanisms, innovations, and clinical translation.
Yanxu Hou, Jiwei Zhang, Bing Huang, Peng Zhan, Xinyong Liu   +4 more
wiley   +1 more source

Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid). [PDF]

ACS Med Chem Lett
Sells CA, Kostyo JH, Gaykar RN, Kara MI, Lallande AT, Kane RR.   +5 more
europepmc   +1 more source