Results 231 to 240 of about 33,100 (295)
Tumor-Selective and Chemical Activation Strategies for Nitrogen Mustard Prodrugs. [PDF]
ChemistryPonnamperumage TNF +7 more
europepmc +1 more source
Hydrogen Sulfide Prodrugs—A Review [PDF]
Acta Pharmaceutica Sinica B, 2015 Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications ...
Binghe Wang, Xingyue Ji, Kaili Ji
exaly +3 more sources
Biocatalytic Approaches Applied to the Synthesis of Nucleoside Prodrugs [PDF]
Biotechnology Advances, 2015 Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome selectivity issues of nucleoside ...
Adolfo M Iribarren +2 more
exaly +2 more sources
Molecules, 2008 The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs.
Ana L. Simplício, John F Gilmer
exaly +4 more sources
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Bioorganic & Medicinal Chemistry Letters, 1998
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell ...
Y, Wei, Y, Yan, D, Pei, B, Gong
openaire +2 more sources
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell ...
Y, Wei, Y, Yan, D, Pei, B, Gong
openaire +2 more sources
1993
To exert its antitumor effects, leucovorin must ultimately become activated by conversion to CH2FH4.* Elevation of this reduced folate cofactor stabilizes the inhibitory ternary complex formed between the FU active metabolite, FdUMP and thymidylate synthase, resulting in suppression of DNA synthesis or repair.1–4 It has been demonstrated both in animal
D G, Priest, J C, Schmitz, T, Walle
openaire +2 more sources
To exert its antitumor effects, leucovorin must ultimately become activated by conversion to CH2FH4.* Elevation of this reduced folate cofactor stabilizes the inhibitory ternary complex formed between the FU active metabolite, FdUMP and thymidylate synthase, resulting in suppression of DNA synthesis or repair.1–4 It has been demonstrated both in animal
D G, Priest, J C, Schmitz, T, Walle
openaire +2 more sources
International Journal of Pharmaceutics, 2004
In 1975 Prof. H. Ringsdorf proposed a model for rational design of polymeric prodrugs [J. Polym. Sci. Symp. 51 (1975) 135]. The model has been the most important basis for research in the field, since it was the first model that took into account both the chemical and biological aspects needed for the design of polymeric prodrugs. This paper deals with
K, Hoste, K, De Winne, E, Schacht
openaire +2 more sources
In 1975 Prof. H. Ringsdorf proposed a model for rational design of polymeric prodrugs [J. Polym. Sci. Symp. 51 (1975) 135]. The model has been the most important basis for research in the field, since it was the first model that took into account both the chemical and biological aspects needed for the design of polymeric prodrugs. This paper deals with
K, Hoste, K, De Winne, E, Schacht
openaire +2 more sources