Results 241 to 250 of about 73,540 (330)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

In Vivo Imaging of a Photoactivatable Platinum Prodrug by Metal-Centered Radiolabeling. [PDF]

J Am Chem Soc
Firth G, Kim J, Shi H, Sunassee K, Zwaagstra O, Schilden KV, Blower PJ, Sadler PJ, Imberti C.   +8 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Enhancing Oral Bioavailability of Poorly Water-Soluble Natural Products via Lipid-Drug Conjugates. [PDF]

Pharmaceutics
Zou X, Zhang B, Mei L, Han S, Chen K.
europepmc   +1 more source

Functional matrix engineering enables aggregate-state photophysics in tumor-responsive organic NIR-II phototheranostics. [PDF]

Mater Today Bio
An L, Ou C, An H, Sun H, Mou X, Dong X, Cai Y.   +6 more
europepmc   +1 more source

MEP Pathway: First-Synthesized IspH-Directed Prodrugs with Potent Antimycobacterial Activity. [PDF]

Microorganisms
Allamand A, Noël-Duchesneau L, Ettelbruck C, De Luna E, Lièvremont D, Grosdemange-Billiard C.   +5 more
europepmc   +1 more source

Human Serum Albumin as a Prodrug Carrier for Tumor Therapy: Mechanisms, Applications, and Future Perspectives. [PDF]

Pharmaceutics
Shang Y, Wang S, Yan Y, Tian E, She L, Ma Z.   +5 more
europepmc   +1 more source

Asymmetrically Disubstituted Pyrenebutyrate Complexes of Pt(IV) as Cisplatin Prodrugs with Improved Anticancer Activity. [PDF]

Molecules
Mihaylova R, Mihaylova V, Burdzhiev N, Ivanov ID, Petkova Z, Momekov G, Momekova D, Ahmedova A.   +7 more
europepmc   +1 more source