Results 251 to 260 of about 73,540 (330)

Hydrogen sulfide prodrugs—a review [PDF]

Acta Pharmaceutica Sinica B, 2015
Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications ...
Binghe Wang, Xingyue Ji, Kaili Ji
exaly   +4 more sources

Cyclization-activated Prodrugs [PDF]

Molecules, 2007
Many drugs suffer from an extensive first-pass metabolism leading to druginactivation and/or production of toxic metabolites, which makes them attractive targets forprodrug design.
Nuno Vale, P Gomes, R Moreira
exaly   +5 more sources

Some of the next articles are maybe not open access.

Related searches:

Prodrugs in medicinal chemistry and enzyme prodrug therapies

Advanced Drug Delivery Reviews, 2017
Raoul Walther, Alexander Zelikin, Jarkko Rautio   +2 more
exaly   +2 more sources

Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives

Medicinal research reviews (Print), 2023
The burgeoning prodrug strategy offers a promising avenue toward improving the efficacy and specificity of cytotoxic drugs. Elevated intracellular levels of glutathione (GSH) have been regarded as a hallmark of tumor cells and characteristic feature of ...
Jintao Zhao, Xinming Li, Tao Ma, Bing-Bing Chang, Baoxin Zhang, Jianguo Fang   +5 more
semanticscholar   +1 more source

Antiparkinson Prodrugs [PDF]

Molecules, 2008
Parkinson`s disease (PD) is a progressive, neurodegenerative disorder whichinvolves the loss of dopaminergic neurons of the substantia nigra pars compacta. Currenttherapy is essentially symptomatic, and L-Dopa (LD), the direct precursor of dopamine(DA), is the treatment of choice in more advanced stages of the disease.
Antonio di Stefano, Piera Sozio
exaly   +5 more sources

Do Drug‐likeness Rules Apply to Oral Prodrugs?

ChemMedChem, 2021
This paper describes a comparative analysis of the physicochemical and structural properties of prodrugs and their corresponding drugs with regard to drug‐likeness rules. The dataset used in this work was obtained from the DrugBank.
Ícaro F. Protti, D. Rodrigues, Sofia K. Fonseca, R. Alves, R. B. Oliveira, V. Maltarollo   +5 more
semanticscholar   +1 more source

Prodrugs for Amines [PDF]

Molecules, 2008
The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs.
Ana Luisa Simplicio, John F Gilmer
exaly   +4 more sources

Supramolecular prodrugs based on host-guest interactions.

Chemical Society Reviews, 2020
Classic prodrug strategies rely on covalent modification of active drugs to provide systems with superior pharmacokinetic properties than the parent drug and facilitate administration.
Wen-Chao Geng, J. Sessler, Dong-Sheng Guo   +2 more
semanticscholar   +1 more source

Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy.

Angewandte Chemie, 2020
In spite of widespread applications for cancer treatment, chemotherapy is restricted by several limitations including low targeting specificity, acquired drug resistance, and concomitant adverse side effects.
Xiangjie Luo, Xuanqing Gong, Liyun Su, Hongyu Lin, Zhaoxuan Yang, Xiaomei Yan, Jinhao Gao   +6 more
semanticscholar   +1 more source

Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel nanomedicines.

Journal of Controlled Release, 2020
Many drug molecules that are currently in the market suffer from short half-life, poor absorption, low specificity, rapid degradation, and resistance development. The design and development of lipophilic prodrugs can provide numerous benefits to overcome
N. Fattahi, M. Shahbazi, A. Maleki, M. Hamidi, A. Ramazani, H. Santos   +5 more
semanticscholar   +1 more source