Results 271 to 280 of about 73,540 (330)
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Current Medicinal Chemistry, 2002
Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).
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Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).
openaire +2 more sources
Recent advances in the synthesis, stability, and activation of platinum(IV) anticancer prodrugs
, 2021Zou-Feng Xu +3 more
semanticscholar +1 more source
Il Farmaco, 1999
An overview of the different heterocyclic NO-releasing compounds is given. Mesoionic heterocycles like sydnone imines are one example. This class is discussed on the synthesis and the mechanism of NO formation from Molsidomine and its first metabolite SIN-1.
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An overview of the different heterocyclic NO-releasing compounds is given. Mesoionic heterocycles like sydnone imines are one example. This class is discussed on the synthesis and the mechanism of NO formation from Molsidomine and its first metabolite SIN-1.
openaire +2 more sources
The expanding role of prodrugs in contemporary drug design and development
Nature reviews. Drug discovery, 2018J. Rautio +3 more
semanticscholar +1 more source
Disulfide bond-driven nanoassembly of lipophilic epirubicin prodrugs for breast cancer therapy
Journal of Pharmaceutical InvestigationHaimeng Yuan +11 more
semanticscholar +1 more source
Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
Journal of Controlled Release, 2008F. Kratz
semanticscholar +1 more source
The landscape of small-molecule prodrugs
Nature reviews. Drug discoveryZachary Fralish +4 more
semanticscholar +1 more source
Pt(IV) Prodrugs with NSAIDs as Axial Ligands
International Journal of Molecular Sciences, 2021Elena Beloglazkina +2 more
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