Results 261 to 270 of about 73,540 (330)
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Ceria Nanozyme and Phosphate Prodrugs: Drug Synthesis through Enzyme Mimicry.
ACS Applied Materials and Interfaces, 2021Nanozymes can mimic the activities of diverse enzymes, and this ability finds applications in analytical sciences and industrial chemistry, as well as in biomedical applications.
Raoul Walther +5 more
semanticscholar +1 more source
Bioorganic & Medicinal Chemistry Letters, 1998
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell ...
Y, Wei, Y, Yan, D, Pei, B, Gong
openaire +2 more sources
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell ...
Y, Wei, Y, Yan, D, Pei, B, Gong
openaire +2 more sources
Click and release: bioorthogonal approaches to "on-demand" activation of prodrugs.
Chemical Society Reviews, 2019Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups ...
Xing-Yue Ji +6 more
semanticscholar +1 more source
Journal of Controlled Release, 2020
Albumin-based nanomedicines are important nanoplatforms for cancer drug delivery. The drugs are either physically encapsulated or covalently conjugated to albumin or albumin-based nanosystems.
Lingqiao Hao +5 more
semanticscholar +1 more source
Albumin-based nanomedicines are important nanoplatforms for cancer drug delivery. The drugs are either physically encapsulated or covalently conjugated to albumin or albumin-based nanosystems.
Lingqiao Hao +5 more
semanticscholar +1 more source
Recent trends in in-situ enzyme-activatable prodrugs for targeted cancer therapy.
Bioconjugate chemistry, 2020Enzyme-activatable anticancer prodrugs are modified medications that are composed of an anticancer drug, cleavable linker, and functional moiety. The purpose of such a prodrug structure is to generate multipurpose functions that traditional drugs cannot ...
In-Cheol Sun +3 more
semanticscholar +1 more source
1993
To exert its antitumor effects, leucovorin must ultimately become activated by conversion to CH2FH4.* Elevation of this reduced folate cofactor stabilizes the inhibitory ternary complex formed between the FU active metabolite, FdUMP and thymidylate synthase, resulting in suppression of DNA synthesis or repair.1–4 It has been demonstrated both in animal
D G, Priest, J C, Schmitz, T, Walle
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To exert its antitumor effects, leucovorin must ultimately become activated by conversion to CH2FH4.* Elevation of this reduced folate cofactor stabilizes the inhibitory ternary complex formed between the FU active metabolite, FdUMP and thymidylate synthase, resulting in suppression of DNA synthesis or repair.1–4 It has been demonstrated both in animal
D G, Priest, J C, Schmitz, T, Walle
openaire +2 more sources
International Journal of Pharmaceutics, 2004
In 1975 Prof. H. Ringsdorf proposed a model for rational design of polymeric prodrugs [J. Polym. Sci. Symp. 51 (1975) 135]. The model has been the most important basis for research in the field, since it was the first model that took into account both the chemical and biological aspects needed for the design of polymeric prodrugs. This paper deals with
K, Hoste, K, De Winne, E, Schacht
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In 1975 Prof. H. Ringsdorf proposed a model for rational design of polymeric prodrugs [J. Polym. Sci. Symp. 51 (1975) 135]. The model has been the most important basis for research in the field, since it was the first model that took into account both the chemical and biological aspects needed for the design of polymeric prodrugs. This paper deals with
K, Hoste, K, De Winne, E, Schacht
openaire +2 more sources
Dalton Transactions, 2019
Cisplatin plays a pivotal role in the treatment of various malignant tumors, but its therapeutic effects are hampered by drug resistance. Pt(iv) prodrugs represent a promising class of "non-conventional" platinum-based anticancer agents to circumvent ...
Zhigang Wang, Zhi-Qin Deng, G. Zhu
semanticscholar +1 more source
Cisplatin plays a pivotal role in the treatment of various malignant tumors, but its therapeutic effects are hampered by drug resistance. Pt(iv) prodrugs represent a promising class of "non-conventional" platinum-based anticancer agents to circumvent ...
Zhigang Wang, Zhi-Qin Deng, G. Zhu
semanticscholar +1 more source
Prodrugs for targeted cancer therapy
Expert Review of Anticancer Therapy, 2019Introduction: Prodrugs have been used to improve the selectivity and efficacy of cancer therapy by targeting unique abnormal markers that are overexpressed by cancer cells and are absent in normal tissues.
Carla Souza, D. S. Pellosi, A. Tedesco
semanticscholar +1 more source
Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation.
Journal of Medicinal Chemistry, 2019A bottleneck for developing CO-based therapeutics is the lack of a safe and controllable delivery form. Herein, we describe efforts toward organic CO prodrugs with dual-responsive endogenous triggers. One representative CO prodrug showed significant anti-
Xing-Yue Ji +8 more
semanticscholar +1 more source