Results 121 to 130 of about 4,729,806 (295)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
BuildingsDeveloping guidelines for designing robot-inclusive spaces has been challenging and resource-intensive, primarily relying on physical experiments and observations of robot interactions within the built environment.
Anilkumar Ezhilarasu +4 more
doaj +1 more source
Which senses dominate at different stages of product experience? [PDF]
, 2009 In the area of product design, sensory dominance can be defined as the relative importance of different sensory modalities for product experience. Since product experience is multisensory, it is interesting to know which sensory modality plays a leading ...
Fenko, Anna +2 more
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Product Sound Design: An Inter-Disciplinary Approach? [PDF]
, 2009 The practice of product sound design is relatively new within the field of product development. Consequently, the responsibilities and the role of a (sound) designer are not very clear.
van Egmond, René, Özcan, Elif
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Dual-structure-breaking electrolyte enables practical cadmium-metal battery
Nature CommunicationsHigh-energy aqueous metal batteries are promising candidates for the next-generation energy storage systems but face critical challenges of dendrite and corrosion in metal negative electrodes.
Yang-Feng Cui +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Education SciencesStudents’ comprehension of ethical principles and their application in the realm of AI technology play a crucial role in shaping the efficacy and morality of assessment procedures.
Alexandra Maria Lazăr (Cățeanu) +4 more
doaj +1 more source