Results 101 to 110 of about 6,311,964 (280)

New Product Development in Virtual Environment [PDF]

open access: yes
Purpose - The literature on the topic has evolved exponentially since eight years ago. Relaying on a review of studies published in recent years, this article proposes and discusses a framework which incorporates a set of virtual teams involved in a new ...
Ahmed, Shamsuddin   +2 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Product Development 2.0 [PDF]

open access: yes
Web 2.0 principles will not only revolutionize the web experience, the design pattern and the business models of software companies. They can indeed be applied to a lot of industries for new approaches to product development.
Hinchcliffe, Dion
core   +1 more source

Performance management at design actvity level [PDF]

open access: yes, 2001
The overriding aim of much of the engineering design research is to improve the performance of the design process, and consequently the product development process. Much has been written within the product development literature on the performance of the
Duffy, A.H.B., O'Donnell, F.J.
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Agile values and their implementation in practice [PDF]

open access: yes, 2015
Today agile approaches are often used for the development of digital products. Since their development in the 90s, Agile Methodologies, such as Scrum and Extreme Programming, have evolved.
Escalona Cuaresma, María José   +2 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Area-Efficient Decimation Filter with 50/60Hz Power-Line Noise Suppression for ΔΣ A/D Converters

open access: yesSICE Journal of Control, Measurement, and System Integration, 2017
This paper introduces a new digital filter utilizing a SINC filter used in ΔΣ A/D converters and featuring 50/60Hz power-line noise rejection.
Hideki Kuribayashi, Tetsuya Kajita
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Product Development in the World Auto Industry [PDF]

open access: yes
macroeconomics, auto industry, management efficiency ...
Kim B. Clark   +2 more
core  

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