Advances in Processing Agri-Food and Aquatic By-Products and Residues for New Food Product Development. [PDF]
FoodsMorais AMMB, Morais RMSC.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
PRODUCT DEVELOPMENT IN PRODUCTION – NETWORKS
International Journal of Industrial Engineering and Production Research, 2012 This paper presents an overview of new approaches in rapid product development in production networks from design points of view. The manufacturing industries are changing their focus to global sourcing as a means to improve performance and enhance competitiveness.
openaire +1 more source
Drug Product Development of Lipid Nanoparticle-Based mRNA Therapeutics and Vaccines. [PDF]
Wiley Interdiscip Rev Nanomed NanobiotechnolKersten G +4 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Exploring New Product Development: Acceptance of Textured Vegetable Protein With Baru By-Product in Plant-Based Burgers. [PDF]
Food Sci NutrRebellato AP +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Effects of Concurrent Product Development on Product Development Performance
, 2009 The intensive competition in global world markets has shown that existence of enterprises is only possible by ensuring customer satisfaction. Ensuring customer satisfaction is possible by developing products that can meet expectations of customers.
Yayla, Yeşim, Akyüz, Birol
openaire +1 more source
State of the industry: integration of 3Rs principles and new approach methodologies in non-clinical product development through fit-for-purpose. [PDF]
Front Med (Lausanne)Poppenborg SM, Webster DA, Carlsson B.
europepmc +1 more source