Results 201 to 210 of about 1,775,217 (266)

The Platform Technology Approach to mRNA Product Development and Regulation. [PDF]

Vaccines (Basel)
Skerritt JH, Tucek-Szabo C, Sutton B, Nolan T.   +3 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Navigating regulatory and analytical challenges in live biotherapeutic product development and manufacturing. [PDF]

Front Microbiomes
Microbiome Therapeutics Innovation Group, Barberio D.   +1 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Comparison of biological properties of human adipose tissue-derived mesenchymal stem/ stromal cells from healthy and diabetic donors: consequences for cell-based medicinal product development. [PDF]

Cardiovasc Diabetol
Dudek P, Łabędź-Masłowska A, Madeja Z, Zuba-Surma E.   +3 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Product development and characterization of a lipid-based Ayurvedic polyherbal formulation: Kalyanaka Ghrita. [PDF]

J Ayurveda Integr Med
Singh Y, Ansari AA, Sharma RP, Parhate SM, Singh TR.   +4 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Vegetable Waste in the Retail Sector: Evaluation and Possibilities for Use in New Product Development. [PDF]

Foods
Chagas EGLD, Garcia VADS, Lourenço CAM, Vanin FM, Yoshida CMP, Carvalho RA.   +5 more
europepmc   +1 more source

Standalone Regulatory Agreements for Product-Development Collaborations in the Medical Products Industry. [PDF]

Ther Innov Regul Sci
Wilhelm ME, Pire-Smerkanich N, Richmond FJ.   +2 more
europepmc   +1 more source