Results 191 to 200 of about 1,775,217 (266)

Enhancing Clinical Trial Sites in Low- and Middle-Income Countries to Facilitate Product Development in Response to the COVID-19 Pandemic. [PDF]

Clin Infect Dis
Kang SSY, Tadesse BT, Jeon HJ, Fallah MP, Dereje N, Ilesanmi OS, Abay SM, Tekle BI, Son HG, Shrestha L, Shrestha A, Ramiso HV, Canouet V, Kim Y, Asante KP, Anim J, Kaali S, Capeding MR, Jani IV, Capitine I, Mahumane A, Wartel TA, Haselbeck AH, Saluja T, Marks F.   +24 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Is Kraft Pulping the Future of Biorefineries? A Perspective on the Sustainability of Lignocellulosic Product Development. [PDF]

Polymers (Basel)
Rajan K, Berton P, Rogers RD, Shamshina JL.   +3 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

QbD product development: rapid optimization and scale-up of PBAE-based siRNA delivery <i>via</i> DoE-guided microfluidics.

RSC Pharm
Kromer APE, Eller LJM, Jürgens DC, Merkel OM.   +3 more
europepmc   +1 more source

Integrate & balance aspects for safe and sustainable innovation: Needs analysis on SSbD categories and product development stage requirements to cover the entire life cycle. [PDF]

Comput Struct Biotechnol J
Larrea-Gallegos GM, Hofer S, Hofstätter N, Punz B, Watzek N, Lölsberg W, Wiench K, Wohlleben W, Aguirre IG, Athanassios N, Sarimveis H, Costa A, Seitz C, Friedrichs S, Exner TE, Hischier R, Marvuglia A, Himly M.   +17 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Gender integration of agricultural innovation: implications for the genetically modified crop product development pipeline. [PDF]

GM Crops Food
Katz E.
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source