Results 21 to 30 of about 6,311,964 (280)

Optimization of Baseplate Hub Design for Swaging Operation

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
Swaging process is studied through a 2-D axisymmetric finite element model with non-linear material models and allowing large deformation. The effects of major baseplate hub geometrical parameters are studied for the case of a single actuator arm with ...
K.C. EE, Peter HAHN, Brett HOLAWAY
doaj   +1 more source

SOFTWARE ENTREPRENEURSHIP: KNOWLEDGE NETWORKS AND PERFORMANCE OF SOFTWARE VENTURES IN CHINA AND RUSSIA [PDF]

open access: yes, 2005
This study examines the impact of entrepreneurs’ network structure and knowledge homogeneity/heterogeneity of their network members on product development, and revenue growth of software ventures in China and Russia.
Batjargal, Bat
core   +3 more sources

Two grass pollen tablets commercially available for allergy immunotherapy display different IgE epitope repertoires

open access: yesClinical and Translational Allergy, 2019
Background The distribution of Pooideae species varies across Europe. Especially, Timothy is less represented in Southern than in Northern Europe. Since allergenic cross-reactivity between pollens from different grasses is only partial, grass pollen ...
Thierry Batard   +7 more
doaj   +1 more source

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

open access: yesmAbs, 2020
Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery.
Zhiqiang Chen   +7 more
doaj   +1 more source

Baseline risk factors associated with immune related adverse events and atezolizumab

open access: yesFrontiers in Oncology, 2023
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer patients in the last decade, but immune-related adverse events (irAEs) pose significant clinical challenges.
Katrin Madjar   +6 more
doaj   +1 more source

Microsystem Product Development

open access: yes, 2006
Over the last decade the successful design and fabrication of complex MEMS (MicroElectroMechanical Systems), optical circuits and ASICs have been demonstrated. Packaging and integration processes have lagged behind MEMS research but are rapidly maturing.
Polosky, M.-A., Garcia, E.-J.
openaire   +3 more sources

Tumor growth inhibition modeling to support the starting dose for dacomitinib

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2022
Dacomitinib is a second‐generation, irreversible EGFR tyrosine kinase inhibitor for first‐line treatment of patients with metastatic non‐small cell lung cancer and EGFR‐activating mutations.
Luke K. Fostvedt   +3 more
doaj   +1 more source

Authorship Weightage Algorithm for Academic Publications: A New Calculation and ACES Webserver for Determining Expertise

open access: yesMethods and Protocols, 2021
Despite the public availability, finding experts in any field when relying on academic publications can be challenging, especially with the use of jargons.
Wei-Ling Wu   +5 more
doaj   +1 more source

Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study

open access: yesmAbs, 2020
Process intensification has shown great potential to increase productivity and reduce costs in biomanufacturing. This case study describes the evolution of a manufacturing process from a conventional processing scheme at 1000-L scale (Process A, n = 5 ...
Jianlin Xu   +11 more
doaj   +1 more source

Molecular Attributes Associated With Refolding of Inclusion Body Proteins Using the Freeze–Thaw Method

open access: yesFrontiers in Microbiology, 2021
Understanding the structure–function of inclusion bodies (IBs) in the last two decades has led to the development of several mild solubilization buffers for the improved recovery of bioactive proteins.
Priyank Singhvi   +10 more
doaj   +1 more source

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