Results 21 to 30 of about 1,775,217 (266)

Productivity Developments Abroad [PDF]

open access: yesFederal Reserve Bulletin, 2000
This article reviews recent productivity trends in foreign industrial countries. The focus of the analysis is on whether productivity abroad has accelerated to an extent comparable to that observed in the United States. The authors find that foreign labor productivity, unlike that of the United States, has not accelerated in the latter half of the ...
Christopher J. Gust, Jaime R. Marquez
openaire   +1 more source

Upstream cell culture process characterization and in-process control strategy development at pandemic speed

open access: yesmAbs, 2022
As of early 2022, the coronavirus disease 2019 (COVID-19) pandemic remains a substantial global health concern. Different treatments for COVID-19, such as anti-COVID-19 neutralizing monoclonal antibodies (mAbs), have been developed under tight timelines.
Jianlin Xu   +4 more
doaj   +1 more source

Product Development vs. Production Development

open access: yesProcedia CIRP, 2014
AbstractThe lifecycle of a product and the lifecycle of the respective production equipment intersect in the production phase of the product, which at the same time represents the use phase of the production equipment. Product development and production development however follow more or less independent pathways, making use of different terminology ...
Vielhaber, Michael, Stoffels, Pascal
openaire   +1 more source

Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches

open access: yesmAbs, 2023
Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood ...
Chunting Zhang   +11 more
doaj   +1 more source

Disease progression modeling of the North Star Ambulatory Assessment for Duchenne Muscular Dystrophy

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2023
Duchenne muscular dystrophy (DMD) is a rare genetic disorder caused by decreased or absent dystrophin gene leading to progressive muscle degeneration and weakness in young boys.
Jennifer E. Hibma   +3 more
doaj   +1 more source

Developments on Product Propagation [PDF]

open access: yes, 2014
Product Propagation (pp) is an algorithm to backup probabilistic evaluations for abstract two-player games. It was shown that pp could solve Go problems as efficiently as Proof Number Search (pns). In this paper, we exhibit three domains where, for generic non-optimized versions, pp performs better (see the nuances in the paper) than previously known ...
Abdallah Saffidine, Tristan Cazenave
openaire   +1 more source

Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction

open access: yesmAbs, 2021
Monoclonal antibody (mAb) interchain disulfide bond reduction can cause a loss of function and negatively impact the therapeutic’s efficacy and safety.
Seo-Young Park   +9 more
doaj   +1 more source

Optimization of Baseplate Hub Design for Swaging Operation

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
Swaging process is studied through a 2-D axisymmetric finite element model with non-linear material models and allowing large deformation. The effects of major baseplate hub geometrical parameters are studied for the case of a single actuator arm with ...
K.C. EE, Peter HAHN, Brett HOLAWAY
doaj   +1 more source

Requirements for Automotive LiDAR Systems

open access: yesSensors, 2022
Light detection and ranging (LiDAR) are fundamental sensors that help driving tasks for autonomous driving at various levels. Commercially available systems come in different specialized design schemes and involve plenty of specifications.
Zhuoqun Dai   +5 more
doaj   +1 more source

Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: a PET substudy interim analysis

open access: yesAlzheimer’s Research & Therapy, 2019
Background We previously investigated low doses (105 or 225 mg) of gantenerumab, a fully human monoclonal antibody that binds and removes aggregated amyloid-β by Fc receptor-mediated phagocytosis, in the SCarlet RoAD (SR) and Marguerite RoAD (MR) phase 3
Gregory Klein   +13 more
doaj   +1 more source

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