Results 41 to 50 of about 3,167,450 (250)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

ANALYSIS OF TECHNOLOGICAL INNOVATIONS MANAGEMENT AT RUSSIAN INDUSTRIAL ENTERPRISES: SOURCES OF FINANCING, INNOVATIVE STRATEGY

Russian Journal of Economics and Law, 2012
The article analyzes technological innovations management at Russian industrial enterprises, basing on the study of financial sources of the innovative-technological activity of industrial enterprises, determining the type of innovative strategy of ...
G. I. Gumerova, E. S. Shaymieva
doaj   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Innovations and Export Performance: Firm-level Evidence from Poland

Entrepreneurial Business and Economics Review, 2016
Objective: The main objective of this article is to study the empirical relationship between innovations and export performance of Polish firms. Research Design & Methods: Our analytical framework refers to the most recent strand in the new trade ...
Andrzej Cieślik, Jan Jakub Michałek, Krzysztof Szczygielski   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Influence of product innovations on financial performance of small and medium-sized enterprises in the Czech Republic

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2012
Objective of this article is to determine possible effect of product innovations on the financial performance of small and medium-sized enterprises in the Czech Republic.
Jakub Tabas, Michaela Beranová, Dana Martinovičová   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Innovative activity and innovative effectiveness: analysis of the gap in Russian processing industry

Вестник университета
Innovation activity of the manufacturing industry organizations in Russia in 20202024 is analyzed. The purpose of the study is to identify the discrepancy between the growth in the number of innovatively active enterprises and the dynamics of innovative ...
E. V. Takmakova, A. G. Zaitsev, E. A. Karelina, I. A. Dolmatovich, G. P. Sorokina   +4 more
doaj   +1 more source