Results 61 to 70 of about 760,836 (304)

Product and Process Innovations in a Horizontally Differentiated Product Market [PDF]

For a market of horizontal product differentiation, the paper examines the effects of the level of competition on the firm’s decision between a product and process innovation.
Pia Weiss
core   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

An Innovative Biodiesel Production

Chemical Engineering Transactions, 2010
Abstract preview not available - see full-text PDF article.
Rocio Maceiras, Angeles Cancela, Monica Rodriguez, Angel Sanchez, Santiago Urrejola   +4 more
openaire   +2 more sources

Integrated Product Policy and Environmental Product Innovations: An Empirical Analysis [PDF]

The European Commission has recently stepped up its promotion of the ?Integrated Product Policy?. The objective of the IPP is to support the realisation of environmental product innovations and thus to achieve a broad reduction of all environmental ...
Rehfeld, Katharina-Maria, Rennings, Klaus, Ziegler, Andreas   +2 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

THE POTENTIAL OF VIRTUAL REALITY AND ARTIFICIAL INTELLIGENCE IN MODELING PRODUCT INNOVATIONS OF VIRTUAL CORPORATION

Економіка та суспільство
This scientific article explores the characteristics of modeling product innovations in virtual corporations that operate in online environments (without physical offices).
Тетяна Кулініч , Василь Головачко   +1 more
doaj   +1 more source

How innovative are UK firms? Evidence from the Fourth UK Community Innovation Survey on synergies between technological and organizational innovations [PDF]

, 2010
Using data from the Fourth UK Community Innovation Survey this paper explores the diffusion of a range of innovative activities (encompassing process, product, machinery, marketing, organization, management and strategic innovations) across 16,383 ...
Arora, Arora, Bartel, Battisti, Berman, Black, Bloom, Bresnahan, Brynjolfsson, Cappelli, Caroli, Cohen, Colombo, Colombo, Edwards, Finegold, Geroski, Hannah, Ichniowski, Ichniowski, Ireland, Karshenas, Leseure, Little, Mansfield, Milgrom, Milgrom, Noteboom, O'Mahony, Perrow, Ruigrok, Saloner, Stoneman, Stoneman, Stoneman, Whittington, Åstebro, Åstebro   +37 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Special economic zones, gender and innovations: new evidence from an emerging economy

Cogent Business & Management
This paper examines how the gender of CEOs affect product and process innovations at the firm level, focusing on how SEZ features affect the gender-innovations nexus.
Charles Godfred Ackah, Robert Darko Osei, Baah Aye Kusi   +2 more
doaj   +1 more source